Barely Significant
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“may be significant”

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In the literature

While RRI values ​​generally remained within the normal range in patients with normal or minimal proteinuria, they approached the upper limit of normal in individuals with low-grade proteinuria; this suggested that RRI values ​​close to 0.70 may be significant in terms of early renal involvement.
The few in vitro experiments mentioned demonstrated that SphK1b expression reduces drug sensitivity in hormone-responsive prostate cancer cells, suggesting that the expression of SphK1a and 1b in prostate cancer patients may be significant in the selection of treatment with the potential to desensitize hormone treatment response [ 33 , 35 , 36 ].
Interventions reported in these cases included corticosteroids and intravenous immunoglobulin (IVIG) as well as fresh frozen plasma, platelets and red blood cell transfusion, plasmapheresis, vitamin K, recombinant factor VIIa (rFVIIa), cyclophosphamide, and/or rituximab; thus, the potential economic impact of an induced coagulopathy associated with exposure to bovine thrombin may be significant.
The unresolved safety concerns of bovine thrombin.
Patient Saf Surg · 2008 · PMC2562998