“may be significant”

It may be significant that even with this responsiveness, resulting phenotypes appeared to shift to subclusters contained within supercluster I, rather than form new clusters distinct from this supercluster.

However, the potential systemic adverse effects of estrogen on patients, especially those with preexisting medical comorbidities, may be significant.

Although the overall complication rate is low and most complications are minor, third molar removal is so common that the population morbidity of complications may be significant.

This distinction may be significant in tailoring rehabilitation programs to the needs of individuals with spinal injury both with and without brain injury.

Besides, as discussed in the preceding sections, the crystal anisotropy may be significant to induced direction dependence in electrical conductivity as it arises from hopping of carriers.

Accordingly, appropriate clinical use of antibiotics to treat or prevent HF may be significant.

Data on the biochemistry and mechanisms initiated by TLR activation may be significant in light of potential therapies for autoimmunity [ 69 , 70 ].

[ 24 ] suggest that in the early stages of the disease, there may be significant enhancement changes on gadolinium-enhanced T1-weighted MRI, potentially due to BBB damage.

For example, (1) there are often important differences in cellular responses between acute shRNA knockdown and stable germline knockout; (2) there may be important differences in the role of ZKSCAN3 in humans and mice; (3) there may be significant differences in transcriptional regulation of autophagy between cancer cells and non-cancer cells.

Their large gape and frequent consumption of fruit suggests they may be significant seed dispersers (Carroll, 1963 ; Coleman, Warburton, & Green, 1983 ), but their predatory impacts on other native fauna have led to them becoming regarded negatively by conservationists (Miskelly & Beauchamp, 2004 ).

However, there may be significant enrichment differences between exosomal and free circulating miR-210, as the latter is increased to a comparably lesser degree.

Furthermore, the program allows for a high noise level, which is particularly suitable for ultrasound-guided procedures, where there may be significant variability in the users’ skill, the intrinsic composition of subjects’ tissue, and ultrasound systems’ image reconstruction algorithms resulting in the variable quality of ultrasound images [ 33 , 34 ].

Except for combined sensitivity, all other diagnostic indicators had decreased to varying degrees, indicating that there may be significant heterogeneity between this study and the other 12 studies.

In particular, reduced expression of SMC3 , RAD21 , NIPBL and ESCO2 induced substantial cohesion defects and numerical CIN, and thus, may be significant, yet unappreciated drivers of cellular transformation and oncogenesis.

Continuing research is likely to further illuminate how such impacts that persist at the genetic level across time may be significant in adaptive reactions to stress within communities such as Native America or the African diaspora.

However, beyond LEO and protection from radiation, the effects of radiation on biological systems may be significant.

Another trouble with the method proposed is that like any analogy, there may be significant differences between the two items being compared.

Since there may be significant difference in height distribution between the current study sample and others, the blood pressure cutoffs for exact height values instead of height percentile categories are proposed to make it more practical and accurate for individual blood pressure assessment.

, 2008 ) relies on assumptions that should be reconsidered in view of recent discoveries: the CCM is not uniquely supplied by the ATP-costly PEPC activity, but, under certain conditions, the contribution through respiration and photorespiration may be significant ( Kromdijk et al. , 2010 ; Sage et al. , 2012 ; Bellasio and Griffiths, 2013 ).

Despite the fact that there is not much of it in the friction material, the difference in the price of the final product may be significant.

At the same time, knowledge about how many parents regret making the decision about parenthood, and what causes this regret, may be significant, not only for representatives of many branches of science, including psychology, psychiatry, sociology, and public health, but also for the social policy of the many countries that treat the quality of life of the family and the child as one of their priorities [ 11 ].

Physical activity during childhood may be significant in the development of motor-skill proficiency in adulthood.

Overall resource savings may be significant when considering the costs of transport, training, drug procurement, social mobilization, monitoring and staff time at all levels of the health service.

The consequences of these variations may be significant when attempting to address consequences of immunogens that exhibit host-specific patterns of infection, such as cytomegalovirus ( Mestas and Hughes, 2004 ; Masopust et al., 2017 ), leading some researchers to suggest that rodents poorly recapitulate human injury or disease-associated inflammatory cascades and to advocate caution in the utilization of rodent models for immune-focused research questions ( Seok et al., 2013 ).

The failure to account for non- specific effects may be significant as expectation has demonstrated a robust influence in the general pain literature [ 29 - 40 ].