“may be significant”

In this pandemic, CHB may be significant comorbidity of preexisting liver illnesses.

While the relevance of altered signaling responses in resting muscle is unclear, the potential molecular crosstalk between two different active muscle groups may be significant; when a muscle is activated and triggered for adaptation, the impact of a preceding systemic release of so called exerkines might be enhanced as compared to the effect on a resting muscle.

Although the proteomic methods used in this work suffer from some limitations, as discussed in further detail in Tarrant et al., 26 any differences in the impurity profile, even if minor, may be significant as these are one of the primary impurities targeted for removal during the purification process. 33 This also provides rationale for further examination of HCPs, when changes to the existing production process are made, in particular on whether or not there is a consequence on the effectiveness of the purification process.

Although different administration routes can all achieve the purpose of analgesia, there may be significant differences in drug bioavailability, time to reach peak blood drug concentration, tissue distribution characteristics, and the incidence of adverse reactions.

al that other factors, such as structural changes, may be significant factors at these elevated temperatures. 19 Unexpectedly, we did not observe a noticeable shift in onset potential for C 2+ products.

Given the challenges with achieving cure, even small differences in efficacy may be significant.

As such, there may be significant differences in regional pleural or transpulmonary pressure, which are either over- or under-estimated based on esophageal pressure [ 9 ].

It may be significant in this context to emphasize that the absence of GnRH downregulation in this proposed low-cost protocol may entail a premature leutinizing hormone surge and luteinization, leading to cancellation of the index cycle.

This study suggests the level of presenteeism in the female office workers may be significant, with many self-managing by reducing work and/or leisure activity and utilizing passive coping strategies.

It may be significant that other signaling receptors are positively and negatively regulated by different trafficking routes ( Sigismund et al., 2008; Di Guglielmo et al., 2003 ).

It may be significant that all the NphyA fusions that cause a cop phenotype were driven by the CaMV 35S promoter, whereas the NphyA(1–686)-YFP-DD-NLS fusion was driven by the native PHYA promoter.

The role of the YY neuropeptide may be significant for this process, but no studies have demonstrated its association with T-2 and HT-2 metabolites.

Nevertheless, most patients (over 80% in each group) were diagnosed with mood, psychotic, or stress-related disorders, and our results may be significant for these particular diagnoses.

Looking ahead, the incipient changes in the Final Common Rule will require revision of the SMART IRB Agreement, revisions that may be significant but that nevertheless afford the opportunity to introduce additional changes, should they be recommended by the stakeholder community and deemed essential to the continued growth of the SMART IRB network and use of the SMART IRB Agreement.

These features may be significant, as they provide insight into the drawing behavior of patients with PD (e.g., greater pressure results in darker spirals, while lighter pressure results in lighter spirals).

Furthermore, there may be significant ankle malunion related to the fibula and talar shift without malunion of the MM component.

The results obtained may be significant in terms of prevention of the development of overweight as well as structural and biomechanical changes in the limb joints and the lumbosacral complex in hemophilia patients. 2.

The parasite, however, appears to have developed redundant salvage pathways to acquire host sphingolipids, which suggests that the contribution of host sources of these lipids may be significant for parasite growth.

Furthermore, this study demonstrated that social and environmental factors, such as lost opportunities for drinking education due to lack of childbirth history, partner’s drinking status, and employment, may be significant risk factors for drinking habits for women on ART treatment.

This may be significant, as it appears that the fetus is incapable of producing IL-6 at the time of birth and is dependent on maternal IL-6 [ 45 ].

Our data indicate that a difference in the level of one particular cytokine between groups may be significant, and yet not meaningful, since the concentrations of many others may as well be abundant.

It has been suggested that chemotherapy-associated weight gain during treatment for early-stage breast cancer may be transient [ 5 ], but if in fact body composition (i.e., an increase in body-fat percentage) and not just weight is altered during treatment with chemotherapy, the long-term health consequences may be significant even if an individual returns to their pre-chemotherapy weight.

Such a large difference in the overall livingness may be significant not only for the synthesis of multiblock copolymers but also for applications where post-polymerization modification is essential to install desired functionality at the chain-end.

It has been hypothesised previously in the literature that microplastic contamination of the base of the marine food web may be significant enough to disrupt the biological pump 20 – 24 (albeit with mechanisms different from what we demonstrate here).

Conclusion Dense, mature cataracts and small pupils both compromise the view for the surgeon and may be significant risk factors for training ophthalmologists.