“may be significant”

There may be significant value in evaluating whether models of supported self-management and rehabilitation used in long-term conditions care could be transferred to individuals with cancer ( Department of Health, 2005 , 2007 , 2009 ).

Previous studies have shown that the presence of G rich sequences and motifs may be significant for gene activity and function.

Thus, adhering to physician recommendations for OSA screening and treatment requires a high degree of health literacy, and there may be significant consequences for those patients with low literacy skills.

A further difference from natural host populations that may be significant to parasite virulence is the often low level of genetic variation in farmed host populations, which may favour the spread of diseases (Altermatt and Ebert 2008 ; Ganz and Ebert 2010 ).

A limitation of using mice to understand mechanisms in these experiments is that there may be significant differences in the immune system and corneal physiology between the mouse and human.

There may be significant delays between the irradiation of test films on a brachytherapy unit and corresponding reference films from an external beam linear accelerator (used to provide uniform film dose irradiation) due to practical equipment access issues within a radiotherapy department.

Indeed, the depth levels of MAC procedures may be significant, at times becoming general anesthesia without airway protection. 19 Our current study lays the foundation for future studies, given the versatility of this new device during complex EUS/ERCP procedures.

In addition, the clinical efficacy of stimuli-responsive electrospun nanofibers is uncertain, and the difference in response to these agents implanted in each individual may be significant.

While both mutants displayed properties typical of wild-type Cx43 (Cx43WT), they also showed unexpected properties that challenge current models of channel function and may be significant for the cardiac phenotypes of the (S3A, S3E) transgenic mice, as well as for the pathophysiology of cardiac ischemia and arrhythmogenesis. 2.

The contribution of small monodisperse particles, that would reside in the channels along the [100] axis, may be significant only for the sample with 2.3 wt% Cu.

Moreover, according to the study of Almerie and Kerrigan [ 24 ], montelukast by acting through the antiviral effect, or by suppression of augmented cytokine release may reduce the severity of immune-mediated multiorgan damage, what may be significant especially in COVID-19 patients with central obesity and metabolic syndrome.

With respect to the effects on long-term plasticity, since LTP reaches normal levels at the later phase, we predict that some tests in Hirano body mice will indicate normal capacity for learning and memory, although deficits related to the impairment of the early phase of LTP may be significant.

The findings indicate that the CXCL12/CXCR4 pathway may be significant in ischemia–reperfusion injury of vital organs.

These findings suggest that if PRP is effective, its effects may manifest in the earlier post-injection period, and placebo effects may be significant in any injection-based intervention for knee OA. 4.3.2.

Collectively, information reviewed herein will serve as a comprehensive reference for the actions of mTOR in IR injury and may be significant for the design of future research and increase the potential of mTOR as a therapeutic target.

37 - 39 These findings may be significant, because SFN-induced DNA damage is repaired predominantly through homologous recombination, 40 and destabilizing a critical repair protein in this pathway, CtIP, provides an avenue for synthetic lethality. 41 HDACs maintain CtIP in the deacetylated state, whereas GCN5-mediated acetylation shunts CtIP into autophagy-mediated degradation. 7 We observed that ITC-induced CtIP acetylation and turnover coincided with the activation of an autophagic response, the degree of which increased with length of the alkyl side chain ( Fig. 6 ).

These results may be significant in the early detection of RCC since the present work may provide new targets.

These alterations may be significant for increasing CD pathogenesis by contributing to the disease onset.

At a later stage the corresponding murmur was no longer present and arch aorto- graphy showed complete obstruction of the left carotid with a tight stenosis of the right internal carotid where a murmur persisted. A variable murmur may therefore indicate a variable degree of obstruction, yet still have been significant when heard; and a murmur may be significant of stenosis yet the stenosis producing it may not be the one which matters.

Despite this limitation, the usefulness of this analysis Is not greatly diminished as if taken along with future research into the effects of socio-economic status and other factors, there may be significant clustering that does not overlap giving these results utility.

The present dual-phase-lag theory diminished the magnitudes of the examined variables, which may be significant in some practical applications.

The agro-pastoral ecotone that we studied is a transitional zone between regions with a continental climate and regions with a monsoon climate, so climate change in this region is unstable, and the impact of land-use changes caused by human activities on regional temperature increases may be significant.

Similarly, the inter-observer variations in the results of TEM may be significant since the technique requires high level of expertise in cytological assessment.

Although budget constraints for licensing contents and the local use of scientific journals are good arguments in favour of interlibrary loan use in remote locations (such as the territorial health ministries), the loss of productivity resulting from excessive time spent in pursuit of information may be significant for the provincial health ministries.

While we do not have district-level information about hourly diurnal cycles of fire activities due to a lack of comprehensive in-field studies, our broad conclusion is that there may be significant benefits yielded by encouraging fires to be set earlier (10:00–13:00 LT) in the day rather than later (14:00–17:00 LT).