“may be significant”

It should also be noted that there may be significant regional differences in the expression of CBS in the DS brain.

Additionally, the financial impact of TB and CRDs may be significant when experienced together.

The emerging concept is that multiple factors including microvascular disease, coronary vasospasm, and others may be significant contributors to myocardial ischemia, and that obstructive CAD is one of multiple potential causes [ 1 ].

It is possible, for example, that efficient recognition of Gram-negative heat shock proteins may be significant in combatting infection and it has already been shown that recognition of human heat shock proteins has a role to play in atherogenesis ( 23 ).

Indeed, time above IC 50 may be significant. 39 One observation with tofacitinib dosed QD vs BID suggests that some JAK effects may be more sensitive to daily drug holiday.

The consequences of misinterpretation may be significant, with this potentially not only altering patients’ compliance with treatment regimens, yet it may also have a psychological impact on the individuals.

Animal studies have shown that the VNS may be a crucial communication pathway for FMT and that sigma-1 receptors (Sig-1R) and NLRP3 inflammasomes, which mediate neurochemical effects, may be significant targets for FMT efficacy. 49 , 50 Numerous clinical studies have demonstrated that FMT markedly alleviates depression symptoms and effectively treats recurrent Clostridium difficile infections. 51–53 However, despite being less invasive, the long-term safety of FMT (eg, risks of infection and metabolic abnormalities) remains uncertain, and the lack of standardized clinical protocols limits its current application.

The growth rate may be significant enough to cause two cells to be filled at one time step.

These include increases in heart rate, cardiac index, and decreases in both mean arterial pressure and systemic vascular resistance index, 2 , 3 which may be significant for patients with high-risk cardiovascular conditions.

Transient corneal epithelial edema from surgery may explain the epithelium thickening at 1 week.[ 15 ] Laser ablation surgery may impair corneal epithelial sensory nerves and diminish nutritional function, causing corneal epithelium thinning at 1 month postoperatively.[ 16 ] Regeneration of subepithelial corneal nerves typically becomes active around 3 months postoperatively.[ 2 ] Our research found corneal epithelium thickening in the third month postoperatively, suggesting corneal nerve regeneration may be significant in postoperative remodeling.

Most patients require several second-line treatments whose burden and associated complications may be significant.

Coaches who attended a workshop demonstrated good baseline knowledge of injury risk and prevention and it may be significant changes were unobtainable due to a ceiling effect.

The original analysis did not include a second TNL gene, which may be significant since TNL genes like RPS4 signal through EDS1 , while coiled-coil (CC)-NBS-LRR genes like RPS2 and RPM1 require NDR1 [17] .

This finding suggests that there may be significant physiological heterogeneity within the female sample, particularly regarding differences in HPG axis status during puberty, childbearing years, and the perimenopausal period.

There may be significant motivation from patients to better understand their clinicians’ opinions and perspectives on activities in their daily lives, be part of more low-stress environments, and feel more comfortable in the medical setting.

Distinct from the CA1 and CA3 regions, which are selectively injured in BCCAO and BCAS chronic models, the CA2 region of the hippocampus is involved in social recognition memory and may be significant in the context of BCCAGO model behavioral and cognitive changes ( Piskorowski and Chevaleyre, 2023 ; Bennett et al., 1998 ; Soria et al., 2013 ; Khan et al., 2015 ).

Before proceeding to use of NPWT in human extravasation injuries, demonstration of the difference of scar maturation of the extravasation ulcers between the NPWT applied group and conventional dressing group in larger animals, such as pigs may be significant.

In addition, we did not classify amblyopia according to clinical status such as mild/moderate/severe and there may be significant differences in refractive error (spherical equivalent) among the groups, and this parameter was not included in our analysis.

maltophilia may be significant, given that this species is intrinsically resistant to many broad-spectrum antimicrobial agents, including carbapenems, as a result of production of inducible chromosomal metallo- and serine-β-lactamases (L1 and L2) ( 40 ).

Hospitals concentrate many infected patients and may be significant spreaders of the disease.

Our simulations suggest that this contribution to the stratospheric CO budget may be significant during summertime, which is consistent with the observed δ 13 C-CO and δ 18 O-CO at high altitudes.

The loss of the RNFL is more localized in mild to moderate glaucoma, and there may be significant correlations between localized RNFL loss and localized retinal flow.

This is particularly important for adolescents who may seek greater autonomy in healthcare decisions [ 16 ], and for an intervention where they may be significant aesthetic and comfort‐related implications.

There may be significant differences in the antibody-antigen- complement relationships when these intrinsic antigens are compared with small haptenic groups coupled to proteins of the erythrocyte membrane.

The 4th-ranking gene, SYT1, plays a crucial role in synaptic function and is elevated in the CSF of AD patients, where its synaptic dysfunction may be significant.