Barely Significant
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“may be significant”

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In the literature

Despite that the majority of translational work focuses on IL-17A (given the body of preexisting work based on psoriasis), significant elevations of other IL-17 isoforms, including IL-17C and IL-17F, are observed in hidradenitis suppurativa tissue, 81 , 82 and these may be significant contributors to disease activity that are not targeted by anti-IL-17A therapies alone.
The present study adds to this literature and illustrates how the careful analysis of DA use and its determinants could drive a program of research that empirically validates the characteristics of optimal DA design, development, and implementation. Regression analyses explored demographic variables that may be significant predictors of dimensions of DA use, including follow-through on the initial DA website login; frequency of logging in thereafter; total active time spent on the DA website; and proportion of total DA content viewed.