“may be significant”

However, in the described case of obese people, epigenetic changes related to inflammation may be significant (Dorneles et al. 2016 ).

Shulman and colleagues (2016) identify several refinements of the dual-systems model that we endorse, especially the prediction that social contexts (especially peer contexts) may be significant moderators of many developmental effects.

However, they may be significant when using rats as models in experimental research focusing on the alimentary canal [ 155 ].

Simple heterozygous mutations in ETFA may be significant, since such mutations in ACAD cause adult onset disease. 24 The patient's ETFA mutation encodes a T171I substitution, which decreases thermal stability of the protein, and is over‐represented in patients with the hyperammonemia‐associated disease of very‐long‐chain acyl‐CoA dehydrogenase deficiency. 25 The second mutation was in ORNT2, which encodes a urea cycle ornithine transporter with 88% amino acid identity to ORNT1 (Figure 1 A). 12 Functional redundancy from ORNT2 may explain the mild phenotype of ORNT1 deficiency relative to other urea cycle disorders.

Since B vitamins are directly or indirectly involved in a variety of biological processes, including energy and protein metabolism, maintenance of neurological function, and even relatively short-term deficiencies may accumulate detrimental effects, their contribution to the complex etiology of sarcopenia may be significant and may vary with its stage.

In ferroelectric oxide materials, which have typically modest energy band gaps, the density of extrinsic charge carriers may be significant to induce accumulation or depletion layers at the interface [ 32 ] and stabilise ferroelectric order at ultrathin thicknesses by screening the depolarising field associated with the ferroelectric polarisation [ 35 ].

Hence, modulating antioxidant enzymes and oxidative stress may be significant for NAFLD treatment.

It may be significant that the relative mean changes in chemical shift for HMG-D, ZmHMGB1, and HMGB1 (0.028, 0.050, and 0.045 ppm, respectively) increase with increasing tail length (12, 34, and 30 residues, respectively), presumably reflecting increasing affinity of the tails.

Worthlessness and dehumanisation are well-documented in the literature on autistic mental health distress and may be significant in autistic depression, but poorly understood by others ( Bitsika & Sharpley, 2023 ; Cage et al., 2019 ).

Several gene products did have different expressions in MM and pre-MM, which may be significant in that these gene products could play as important factors in the MM progression.

Moreover, seed grain infected with fungi is of poorer quality and has lower yield, so the economic consequences may be significant: it is estimated that approximately 25% of global cereal production and approximately 20% of global plant production may be contaminated with mycotoxins, although the contamination level may vary significantly depending on local weather conditions [ 8 , 9 ].

Additionally, we hypothesize there may be significant cognitive benefits such as increased focus and executive function ( Carelli et al., 2017 ; Angelakis et al., 2007 ), to provide therapeutic effect for those with cognitive impairments, Attention-Deficit/Hyperactivity Disorder ( Lim et al., 2012 ) or Post-Traumatic Stress Disorder ( van der Kolk et al., 2016 ) that the Encephalophone might provide.

Overall, the results suggest that the analyzed miRNAs, lncRNAs, and TFs may be significant targets for regulating the expression of key genes in IDD. 3.4.

Hence, the synthesis of injectable multifunctional biomaterials with superior shape adaptability, biodegradability and good drug release capability may be significant for anti-OS therapy.

Although only a ~5 °C increase in the crystallization temperature was recorded, this change may be significant from the point of view of processing using high-performance methods, such as large parts injection molding, which may bring about the beneficial effects of shortening the technological cycle time [ 30 ], as well as a more uniform crystallinity in part volume [ 31 ].

Because the relatively stable α-helical segments in the secondary structure of PTH (1-34) are important for receptor binding and activation of PTH (1-34), the retention of secondary structure in the PTH/LysDOCA complex may be significant for the bioactivity of PTH (1-34). 28 The formation of nanocomplexes was confirmed by dynamic light-scattering and TEM.

Phenolic compounds present in corn chips supplemented with AP may be significant contributors to their antioxidant capacity; phenolic acids like ferulic, protocatechuic, and p -coumaric acids, in addition to carotenoids and tocopherols, have been identified in AP [ 6 ].

6 Although the financial cost of treatment may be significant in clinical practice, resources have been considered irrelevant to these legal decisions. 2 Ethical perspective In answering whether a life is worth living, ethicists have frequently turned to the theories of well-being, which ask what makes someone’s life go best: these range from subjective views such as hedonism, where pleasure and pain alone are valued, 13 to objective views, where other goods (such as knowledge, autonomy and relationships) are also considered dimensions of well-being. 14 There is a further question of how these well-being judgements should map to treatment decisions.

We also speculated that there may be significant differences between the pharmacokinetic profiles at high (toxic) dosage and low (therapeutic) dosages, which probably provides some clues of the toxic metabolites.

However, primary cells have a limited number of divisions and there may be significant variability between different batches.

The emerging field of non-coding RNAs, which includes both cellular and viral miRNAs, long non-coding (lnc) RNAs, and circular (circ) RNAs, may be significant contributors to angiogenesis ( Khorshidi et al., 2016 ).

We expect that there may be significant differences between settings, given that what is meant by critical thinking seems to be highly contextual, even from moment to moment.

The comparative effectiveness of diagnostic methods for different post-infection time points, dogs of different ages, especially puppies, and breeds, is not well known and the differences may be significant.

However, there may be significant differences in the specific situation of each township in each province, which could lead to deficiencies in the institutional construction and bottom-up logic.

Results suggest that specific factors may be significant psychological correlates of CPTSD symptoms among older adults during the COVID-19 pandemic.