Barely Significant
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“may be significant”

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In the literature

Given how often coinfections were identified in kittens with Tyzzer disease, we believe that exposure to contaminated soil and immunosuppression caused by environmental, immunologic or infectious, and nutritional factors, may be significant predisposing factors for this disease.
Tyzzer disease in 19 preweaned orphaned kittens.
J Vet Diagn Invest · 2023 · PMC9999403
Currently, no studies have investigated the dose-dependent effects or the impact of exposure duration to halogenated anesthetics in clinical settings, although evidence from animal and in vitro research suggests that these factors may be significant. 10 , 50 , 51 , 52 While Beck-Schimmer et al., 35 Lisnyy et al., 33 Nguyen et al., 10 and Koraki et al. 9 performed pharmacological preconditioning for 30 minutes, Rodríguez et al. 19 conducted preconditioning for 20 minutes.