Barely Significant
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“may be significant”

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In the literature

23 Even a slight increase in IOP may be significant enough to jeopardize ocular perfusion, leading to subsequent venous slowing or stasis53. 3 Therefore, elevated IOP and excessive IOP fluctuation in POAG may further interact with systemic hemodynamic disturbances, exerting a detrimental impact on RVO pathogenesis. 24 Together, according to Virchow'
Furthermore, when considering direct transmission of viral pathogens from mother to offspring, the pathological consequences may be significant despite preexisting maternal seroimmunity, as demonstrated by the relevant morbidity and mortality observed after transplacental infections with viruses other than RSV, such as cytomegalovirus (CMV) and pestivirus [32] , [33] .
However, in this study, no open-ended responses explicitly used terms such as “spiritual” or “religious.” Therefore, it is predicted that even if Japanese travelers experience substantial spiritual changes through TTE, they may not recognize these changes as “spiritual.” This tendency suggests that while the transformative effects of TTE may be significant, their interpretation within the Japanese cultural context does not necessarily align with conventional Western conceptions of spirituality. 6.4.