Barely Significant
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“may be significant”

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In the literature

Although the initial costs and time investment in training may be significant, the system offers several advantages, including: immediate access and control: with an in-house CAD/CAM system, surgeons and medical staff have immediate access to the technology, which can be critical in emergency cases or for making quick adjustments to surgical plans; customisation and tailored
There may be significant emotional burden related to medical appointments and surgical interventions, the natural history of the disease in the extended family, feelings of isolation or unfairness, and/or fear of the future, both for the affected individual and other family members.
albus or group C streptococcal phage-associated lysin directly into a cell wall injection site in rabbit skin results in a decrease in the severity and duration of dermal lesions (27). The demonstration that mutanolysin has a profound effect in vivo on PG-APS- induced arthritis may be significant for the study of inflammation, since it provides a unique situation in which the phlogistic agent can be rapidly and specifically inactivated in vivo while the inflammatory response is evolving.