Barely Significant
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“may be significant”

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In the literature

It may be significant that the methionines in CaBP7 and also CaBP8 have been exchanged for conformationally immobile leucine and isoleucine residues, which might help explain the restricted number of targets available for interaction with CaBP7.
Sense and specificity in neuronal calcium signalling.
Biochim Biophys Acta · 2015 · PMC4728190
Independent measurements of the derivative reagent δ 2 H values are possible in some cases, but without accompanying correction for the amine-bound hydrogen in derivatized amino acids, errors in the reported δ 2 H values of amino acid carbon-bound hydrogen may be significant (on the order of 10 to 100‰; Supplementary Figure S7 ; Supplementary Section 4 ).
Information on both basal thermal tolerance and the plasticity thereof can be compared to give insight into hierarchical levels of, and the magnitude and direction of, variation that may exist between species and across different groups (e.g., Hoffmann, Chown & Clusella-Trullas, 2013 ; Faulkner et al., 2014 ), and thus constraints or trade-offs that may be significant for understanding adaptive evolution.
25 Thus, frailty assessment in elderly populations may be significant for patient management personalization, allowing reduction in both excessive complications and costs of undertreatment and overtreatment. 40 , 42 – 44 However, the lack of consensus for a universal definition of frailty for clinical use limits the application of the diagnosis of frailty syndrome in clinical practice.