“may be significant”

Research on AH metabolites may be significant in promoting the study of the pathogenesis of MFS, especially the occurrence mechanism of ocular symptoms.

Since there may be significant baseline characteristic differences between the colistin and tigecycline groups, we used propensity score matching to balance the baseline predictors for colistin or tigecycline use and mortality [ 23 ].

The context of telework can influence important work factors that may be significant for employees’ sustainable employability (i.e., employees’ capacities to function in work and on the labour market throughout their working lives [ 11 ]).

Providing clear information about the risk of SUDEP has not been proven to improve compliance or outcomes; however, there may be significant benefits to these discussions [ 4 , 59 ].

However, considering the positive effects that heterozygosity can have on fitness (Reed & Frankham, 2003 ) and the results from the other experiments presented here, there are reasons to suspect they may be significant. 4.2 Number of heterozygous loci and growth rate plasticity Comparing diploid individuals, we found that the sampled sporophytes showed only two levels of heterozygosity: two and three heterozygous loci.

This observation leads us to propose that DNA methylation shifts are not a general mechanism for controlling short‐term changes in plasticity but may be significant for specific genes.

The implication of GST polymorphisms may be significant as studies suggest that that loss of mu, pi and theta GST genes increase susceptibility to inflammatory diseases, and a genetic deficiency of GSTM1 is associated with increased susceptibility to ozone-related asthma [ 61 ] and to susceptibility to AFB1-mediated damage to human liver cells [ 62 ].

It may be significant that several 14-3-3-binding singletons belong to ancient multi-protein complexes: Rictor, raptor and PRAS40/AKTS1 are in the nutrient-sensing mTOR (mammalian target of rapamycin) complexes; BAD and B2L11 are central components of the apoptotic machinery; and EDC3 (enhancer of mRNA-decapping protein 3) is part of an mRNA-decapping complex [ 44 , 45 ].

Although there may be significant administrative requirements, using multiple registries provides clear advantages in estimating the population-level incidence of cancer-related outcomes for rare cancers.

Additionally, other studies suggested that only nMSI and KRAS and BRAF mutations may be significant markers for prognosis in CRCs [ 19 , 20 , 47 ].

Cd is a characteristic waste product of many industrial processes and is toxic to multiple organs, and it may be significant that the trees used to fuel the woodstove in this study were grown in the vicinity of a waste incinerator. 48 Waste incineration plants have been shown to release Cd as part of the incineration process, 49 , 50 and Pb was also enriched in woodstove PM compared to all other PM with the exception of road tunnel PM.

The detection of GATA3, PAX-8, SDHB, Pax-8, CD10, and other immune indicators may be significant for accurate clinical and differential diagnoses.

Acid phosphatase, a lysosomal enzyme, was shown to be released by MEHP- treated cells. The effect of treatment of CHO cells in different culture media may be significant.

Previous research has indicated that there may be significant barriers preventing health professionals addressing alcohol consumption with pregnant women.

Burden of Hypothyroidism The economic impact of undiagnosed/untreated hypothyroidism may be significant, especially with regard to costs associated with maternal and congenital hypothyroidism [ 14 , 15 ], or with hypothyroid patients having comorbid conditions such as diabetes mellitus [ 16 ].

As a result, there would be a total of five upregulated and 14 downregulated common DEGs identified, and we also tended to believe that these common DEGs may be significant contributors to the increased risk of AMI due to cigarette smoking. 3.4.

However, when we analyze particular density values, differences are observed in the number of prototypes for each class that may be significant.

HDI reported for a given country represents a standardised measure of the social and economic development of that country; however, there may be significant intra-country variations, especially in large medium-HDI countries such as India, where there are notable differences between rural and urban regions.

The vaccine construct lacks the N-terminal region, junction epitope, and minor NVDP-repeat motifs of CSP, which may be significant targets of immunity.

An area for further analysis relates to landscape‐scale effects associated with commercial scale production on the provision of services, as a number of studies suggest there may be significant implications of commercial scale 2G feedstock deployment (Bianchi et al ., 2006 ; Vanloocke et al ., 2010 ; Bourke et al ., 2014 ) not revealed at smaller scales.

However, there may be significant levels of alternatively spliced transcripts that do not pass co-translational quality control mechanisms and are degraded.

Time-restricted eating has been shown to be metabolically beneficial in men and women with polycystic ovarian syndrome, but there may be significant downsides for certain women, particularly those who are pre-menopausal [ 54 ].

Although DBA, an integrated metric of body movement in all three dimensions obtained from accelerometers ( Halsey et al., 2009 ), has been used as a proxy for energy expenditure in a range of species, this method loses accuracy and precision when applied to species that spend a significant amount of time conducting low movement activities or where environmental DBA may be significant (i.e. resting on water or gliding; Fort et al., 2011 ; Jeanniard-du-Dot et al., 2017 ; Halsey and Bryce, 2021 ; but see Duriez et al., 2014 ).

23 , 32 Therefore, there may be significant merit in the early administration of stem cells prior to the occurrence of any additional postnatal lung injury.

Study Limitations and Further Considerations The OXCGRT stringency index is a ‘low resolution’ composite measure that does not account for nuances in sub-national government responses, which may be significant where state-level measures vary widely between jurisdictions (e.g., in the USA).