Barely Significant
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“may be significant”

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In the literature

Practically, however, there may be significant normal tissue sparing with the BH insp protocol as is evident during deep‐inspiration breath hold (DIBH) radiation therapy. 16 , 19 , 24 One reason for the differences between the BH and FB extrema positions is that during BH scanning, patients can contract or relax their abdominal muscles, causing the external fiducial to move significantly without any corresponding changes in lung volume or tumor position.
It is likely that the 4 fenestrations in Nav1.2 and Nav1.4 are differentially sized as a consequence of such amino acid differences between the 4 repeats, but since there may be significant structural differences between eukaryotic and bacterial VGSCs, it is difficult to tell if residues at other positions in the sequence contribute to fenestration bottlenecks in eukaryotic VGSCs or if structural differences contribute to a widening or restriction of the fenestrations in other ways.
More importantly, the difference in interaction energies between each type of multimodal structure is smaller in the solvent phase compared to the gas phase. This points toward the possibility of switching between such structurally similar and energetically close interaction states, which may be significant for the dynamics at the RNA:protein interface.