Barely Significant
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“may be significant”

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In the literature

This ‘exploitation’ of EGR1 function through interaction with TBX2 may be significant in the context of immortalisation, as EGR1 is also known to transcriptionally upregulate p53, p21 WAF1/CIP1 , TGF-β and PTEN; these prominent TSGs are known to perform critical roles in the induction of cellular senescence.