“may be significant”

In general, one expects that there may be significant differences between species in the way single genes get activated.

According to the authors of the TFI questionnaire, a decrease of 13 points or more reflects a change that may be significant for a given person.

While the occasional off-habitat housing is unavoidable (e.g., due to construction), and the overall benefit may be significant (e.g., a more species-appropriate habitat through construction, as well as not sending animals to other facilities and exposing them to potentially significant inter-institutional transport stress), planning should prioritize minimizing the amount of time spent away from the species-specific habitat.

Out-of-pocket payments, which may be significant in some countries, could also prevent IM from accessing mental health services.

In addition, even with such minor increases in immediate time spent, there may be significant time and anxiety sparing gains over a longer period with increased parental understanding and associated supportive actions.

In tumor xenografts, there may be significant individual variations in tumor growth and vascularization, which may influence the NP accumulation and complicate the analysis. 23 , 24 The TCO-functionalized NPs were successfully traced in vivo with the pretargeted method using [ 18 F] 1 .

In light of these studies, the relevance of genetic variation at the LMNA locus to more common diseases affecting populations at large may be significant.

Unfortunately, without prior training and understanding of the software, code, or field of study, there may be significant learning curves (Bernardo and Macht 2021 ).

Second, there may be significant heterogeneity in the types of populations being studied.

This may be significant when one considers the potential effects of long-term exposure of cells to inductive agents; BMP-2, for example, has been linked to the malignant transformation of breast cells [ 12 ], ectopic bone growth [ 10 ], and neurotoxicity [ 13 ].

Within the limitations of this study, it can be concluded that the coping type and the implants divergence may be significant parameters influencing the impression accuracy.

This difference may be significant when analysing latent variables in a factor analysis.

This suggests that the Bax/Bcl-2 ratio may be significant and that it likely affects caspase-3 in mediating the apoptosis linked to inflammation and renal cell loss throughout the development of renal fibrosis.

It may be significant that nearly all of the 50 genes that are strongly up-regulated in synMuv B mutants and during viral infection are clustered in the genome (see S1 Fig and the S5 Data ).

Consequently, NK-EVs may prove helpful for immunotherapy; nevertheless, while proteins or miRNAs in the NK-EVs may be significant, the essential biological components in NK-EVs are still being investigated.

In addition, given that the AK diagnosis may date from several years prior to the survey, recall error for information on disease and treatment history may be significant.

The difference between an 18 point and 10 point graduation (or 100 point if overall percentage is used) may be significant.

The collective results of these analyses indicate that the majority of protein co-expression relationships are preserved between mice and humans, but they also suggest there may be significant effects driven by line that are either species-specific or not well represented in this human network due to differences in proteome coverage.

TNFAIP8 overexpression has frequently been observed in several types of cancer tissues, suggesting that TNFAIP8 may be significant in oncogenesis ( 12 , 16 , 19 ).

The findings of this case series suggest that there may be significant therapeutic potential in the utilization of lubiprostone for the management of clozapine-induced constipation with a low risk of adverse reactions.

In rodent liver, TLC–S affects mitochondrial activity and ATPase function, leading to altered ionic homeostasis, which may be significant for understanding the role of bile acids in liver pathology and colorectal cancer.

For professionals who spend their lives trying to help others, as indicated by the sub-category of ‘Understanding the patient and farmer’s perspectives’, this emotional impact of AMR may be significant. ‘Helplessness’ has been recently explored in this journal among patients who chose to self-medicate with antibiotics for protection against COVID-19 [ 52 ], and a study from India and South Africa reported the helplessness of lower professions in their interprofessional interactions during surgery regarding topics including antimicrobial stewardship [ 53 ].

In recent years, it has been suggested that lifestyle choices may be significant modulators of disease progression.

The worst predictions are for 5 and 6 , and it may be significant that conformations of these two less sterically-hindered substrates are predicted to be twisted but not perpendicular; then the solvent may have a greater influence on the conformation and hence on changes in conjugation energy during ionization.

Considering the small number of included studies, there may be significant heterogeneity, so a random-effects model was used.