“may be significant”

However, studies are limited and there may be significant geographical variation.

Attempts to isolate the CF 3 SO 2 – salt of [V V O(pb)] + and to bind [V V O(pb)] + to a cation-exchange resin from 1 to 2 day-old solutions of V(IV) and pbH 2 were unsuccessful, which indicates that the concentration of [V V O(OH)(pb)] may be significant over time periods <15 months.

Because some features of the CAF phenotype are similar to the senescence-associated secretory phenotype (SASP), it may be significant that platinum treatment has also been found to induce senescence and autophagy in CAFs.

Therefore, we conclude from these experiments that AROS and DBC1 may be significant regulators of the HSR, with AROS having a positive effect on the HSR and DBC1 having a negative effect.

Adequate test sensitivity may be achieved with lower NGS coverage depth in the case of deceased index patient testing on non-neoplastic tissue; however, failure rates due to technical challenges associated with FFPE tissue analysis may be significant [ 46 ]. 4.2 Specific Variant Testing (predictive testing) Where a causative PV has been identified in an index case, predictive testing for at-risk family members can be offered.

These intrinsic relationship analyses may be significant for understanding the chronic myocardial ischemia mainly related to the energy metabolism and glucose metabolism. 3.5.

There are two differences between the enzymes which may be significant for the inhibitor binding MβLs: (1) The distance between Zn(II) ion and Asp124 which interacts with the hydroxyl group and the triazole ring of 2 in NDM-1, is bigger in VIM-2 (16.12 Å, PDB code 4NQ2) than in NDM-1 (2.12 Å, PDB code 4EYL).

In addition, tumor cells treated with elevated temperatures release inflammatory chemokines in an Hsp70 and TLR4-dependent mechanisms and this effect may be significant in CTL programming and tumor cell killing (Chen et al., 2009 ).

The cumulative effects of stimulation paired with tasks may be significant as well; a single session of tDCS with substance-related cues demonstrated opposite effects on event-related potentials compared to repeated sessions of tDCS ( 67 ).

Nevertheless, with the unclear role of weight loss preoperatively through bariatric surgery or weight loss medications, there may be significant benefit for early operative intervention in select patients.

Patient education presents real challenges within the context of oncology care, where treatments are complex, side effects may be significant, care is primarily provided on an outpatient basis and time with patients is limited.

In large hospitals, there may be significant discrepancies between different wards and departments.

However, the rate of local complications after LSA revascularization may be significant leading to higher re-intervention rate and morbidity [ 60 ].

However, approach-related morbidity may be significant in very extensive collections.

We hypothesized that, although the definitions of amenability appear similar, their impact on the indication of whether treatment with DGJ should be initiated may be significant.

This observation may be significant since, if it is true, it could affect how patients are selected in the clinical trials investigating new targeting agents for the KRAS pathway as well as how patients are treated in clinical practice.

• The double-layer structure of the electrolyte, especially for more complex electrolytes must be investigated further, as the effects of the electrode-electrolyte interfacial structure and surface adsorbed species may be significant for the electron transfer kinetics which would ultimately control the CO 2 separation or conversion rate.

Researchers are then responsible for integrating across a suit of hypothesis tests, some that may be significant while others are not, in order to draw an inference.

It may be significant clinically, because attenuating JNK activity could become a differentiation therapy-based approach for skin cancer in general and for tumors developed by familial cylindromatosis patients in particular.

Studies on SVA introduction to breeding herds suggest that personnel and animal movement, as well as dead animal management, may be significant risk factors for disease transmission [ 16 ].

The reason for the above fact may be significant differences in baseline characteristics between the PL-ACS and the CULPRIT-SHOCK populations.

As in resolvase there may be significant conformation changes that occur with activation of recombination ( 34 , 37 ).

Given the inclusion of diverse study types—both qualitative and quantitative—there may be significant heterogeneity in study designs, data collection methods and outcome measures.

However, we note that there may be significant improvements in the performance of the model by incorporating clinical- and laboratory-based findings.

Considering the small number of included studies, there may be significant heterogeneity, so a random-effects model was used.