“may be significant”

We propose an expanded framework for stressors whose effects may accumulate over time or whose interactions may be significant for management.

It is not known whether there may be significant clinical differences in the vascular effects of different ARB or BB drugs in this situation, or whether any benefit is a class effect.

Unfortunately, there may be significant limitations when using these current agents.

The difference between CP- and OX-DNA in the roll of the G6-G7 base-pair step may be significant for HMGB1a binding to Pt–DNA adducts.

One characteristic of MetS is insulin resistance, and changes in skeletal muscle insulin resistance and glucose metabolism may be significant factors in the development of MetS [ 37 ].

This finding supports the notion that the role of the photonic nanojet may be significant.

Thus, the AURKA SNPs may be significant predictors of UCC occurrence and reliable biomarkers of disease progression and metastasis in patients with UCC.

Considering that “the potential consequences of overdiagnosis and overtreatment may be significant and include such harms as the psychological and behavioral effects of disease labelling, physical harms and side effects of unnecessary tests or treatments, unnecessary treatment negatively affecting quality of life, increased financial costs to individuals and wasted resources and opportunity cost

These pathways may be significant pathways closely related to myocardial fibrosis and can serve as important targets for diagnosing and treating myocardial fibrosis-related diseases. 130 Shao et al found that ALKBH5 post-transcriptionally activated forkhead box O3 (FOXO3) by demethylation of m 6 A via YTHDF2, enhanced cerebellar degeneration-related protein 1 antisense (CDR1as) expression, and then activated Hippo signaling pathway conducing to cardiomyocyte apoptosis in DCM mice. 131 Silencing the ALKBH5-FOXO3 m 6 A-FOXO3 mRNA-CDR1as/Hippo signaling pathway may be a promising new treatment idea for DCM.

The effect of this simplification is likely small; however, it may be significant for a small subset of pathologists.

However, these figures do not distinguish between individuals who have never been treated, those who are not currently being treated, and those who are currently being treated; there may be significant differences in the homicide rates between these three groups of individuals with schizophrenia.

While these figures may appear high, they accord well with those reported by Llorca 4 and the fact that over one-fifth of patients had taken measures to circumvent the problem suggests that swallowing problems may be significant.

Imaging data do not allow us to distinguish confidently between mitochondrial Ca 2+ accumulation and a discrete ‘late’ Ca 2+ influx at the midpiece, but it may be significant that 5 μM 2-APB is reported to slow the export of Ca 2+ from mitochondria [ 46 ].

Once again, the difference in the means of the two groups was higher than each of their standard deviations, suggesting that the difference may be significant.

[ 26 ] Furthermore, it is well understood that patients with lower socioeconomic status and healthcare access, specifically African Americans, have a higher prevalence of cardiovascular and metabolic comorbidities.[ 14 ] These medical risks alone, may be significant enough for urologists to offer male slings over AUS to African American men.

The HormR/GAIN/transmembrane helix sequence arrangement is unrelated to the autoproteolysis function of the GAIN domain although it may be significant for the regulation of receptor signalling via intramolecular interactions.

Notably, the BM patients included in this study originated from both SCLC and NSCLC, and there may be significant prognostic differences between patients with BMs from these different origins, which could influence the efficacy of ICI treatments.

There may be significant variations in the developmental status of secondary school students at different grades since individuals develop rapidly in adolescence.

For epicortical electrodes, especially in subdural grids, there may be significant brain shift in the cortical surface to accommodate placement of the subdural grids and CSF leakage; in some cases, the brain surface may shift greater than 1 cm from the original preoperative MR 15 .

The fact that RGN 42 is related to RNA processing may be significant in view of the gene-regulatory roles of noncoding RNAs in general ( Mihailescu, 2015 ) and in CAD ( Bronze-da-Rocha, 2014 ).

This finding may be significant for the examination of different iris pathologies in these specific regions, potentially aiding in the reduction of false positive outcomes.

15 The published data on long-term psychiatric outcome following VGKC complex-associated limbic encephalitis generally, or LGI1 encephalitis more specifically, are scant but suggests that there may be significant residual psychiatric symptoms and that de novo psychiatric features, including anxiety and affective and impulse-control disorders, may develop. 16 Case presentation In August 2013, a right-handed man aged 57 years was admitted to hospital with a week's history of confusion, personality change and a witnessed generalised tonic–clonic seizure.

Specifically, there may be significant heterogeneity in the populations studied and the structure and theoretical approaches of interventions tried.

However, there may be significant value in diagnostic tests that affect the Bayesian probability of cancer, regardless of underlying genetics.

Considering the small number of included studies, there may be significant heterogeneity, so a random-effects model was used.