“may be significant”

Generally, humic substances are the primary metal-binding ligands for trace metals, and most O-containing acid functional groups, such as carboxyls and phenols and relatively low abundance S- and N-containing functional groups, were proved to be metal-binding ligands, and a molecular structure proximal to metal-binding sites may be significant in metal coordination by DOM, creating stable complexes of varying complexing strengths [ 18 , 19 ].

However, the risk of venous thromboembolism may be significant even in patients with minimal change disease. 3 Indeed, several studies have described adult minimal change nephropathy complicated by pulmonary embolism. 22 – 24 Furthermore, adult patients with minimal change disease complicated by acute kidney injury, which are seen more frequently in older adul

The clinical relevance of 0.09 mm/week is modest in absolute terms but may be significant over the 10–16-week follow-up period: a woman with an NLR of 5.0 would be expected to lose approximately 0.45 mm/week more than a woman with an NLR of 1.0, translating to an additional 4.5–7.2 mm over the observation window—a magnitude that approaches or exceeds the measurement error of transvaginal ultrasound (±2–3 mm) but lies at the lower boundary of detectability.

However, mutation rate variability across individuals in a population has not been investigated for RNA viruses or other organisms with high mutation rates, despite evidence that it may be significant.

This highlights that prevalence may be significant in and around urban areas.

There may be significant differences in children's sports environment, psychological development characteristics and implementation conditions of school intervention in such areas, and multi-center and stratified sampling research is needed to further verify the universality of the intervention effect.

It may be significant that a key difference between marsupials and Eutherians is the extent to which extra embryonic tissues support growth in utero with the Eutherian newborn being substantially larger at term, relative to the size of the mother, and distinctly more mature than the marsupial newborn.

The policy implications of these findings may be significant.

Importantly, gut microbiota changes and PCs may be significant and independent predictors of transplant-related mortality. 1 , 33 , 34 This finding highlights a need for continued development of tools for identifying at-risk populations.

The study informs that in hospitals within 50 miles, the difference in average transportation time between air and land is less than 1 h.[ 15 ] This robust transfer system has proven to effectively reduce travel time, although there may be significant cost consequences if implemented in Indonesia that must be borne by the government.

Availability of social support, a variable that may be significant for deprescribing, was not included in the survey.

Given that the conditioned estimate for n-3 fatty acids was relatively unchanged, it appears that the biosynthetic pathway for n-3 fatty acids may be significant in relation to the risk of AD.

Consequently, these may be significant factors influencing the stability of the tear film layer and its contribution to cGVHD-related dry eye.

31 At times the degree of inflammation in the left lower quadrant may be significant.

There may be significant regulatory hurdles to the use of some imaging probes in patients.

After adjusting for confounding factors, the TG level and TG/HDL-C ratio of the three multitudes were still correlated to IR, and these independent indexes may be significant for the diagnosis of IR [ 23 ].

Nonetheless, being SIM-based systems, all these technologies are characterized by fixed service costs that may be significant in case of IoT infrastructures constituted by large quantities of nodes.

Since the photographed graphene layers are three-dimensional structures, there may be significant measurement errors in determining their lateral dimension.

This study also demonstrates novel pathways and new molecular targets that may be significant contributors to endometriosis pathogenesis, inflammation, and nociception pain pathways and provides several new avenues of investigation for future endometriosis pathophysiological studies.

Notably, VZV DNApol E512K faces the Palm and Finger domains and its impact on FOS-binding may be significant since it is linked to FOS R .

The exact effect of medication on the brain networks of patients diagnosed with depression remains relatively unknown in these samples and this may be significant as a variety of medications were used, including medications classified as serotonin-specific reuptake inhibitors, e.g., paroxetine, medications classified as serotonin and noradrenaline reuptake inhibitors such as venlafaxine, and drugs classified as tri-cyclic antidepressants such as amitriptyline.

8 These results carry at least 2 important clinical implications: (1) they substantiate prior claims that no amount of alcohol is protective against cardiovascular disease, and (2) they newly demonstrate that the adverse effects of alcohol unduly affect those who consume heavily, implying that for an equivalent reduction in alcohol intake, the improvements to cardiovascular health may be significant for heavier drinkers but only slight for those who consume modestly.

However, the number of patients included in this study was limited, and the associated bias may be significant.

The absence of oligodendroglia and microglia may indicate that there may be significant deficits in this brain with heterotopia which may interfere with the migrating neurons and the proliferation of supporting glia; how this attributes to the formation of the heterotopia remains unclear.

Considering the small number of included studies, there may be significant heterogeneity, so a random-effects model was used.