“may be significant”

We speculate that there may be significant differences in immune checkpoint, T cell, and APC cell inhibition between the high-risk and low-risk groups, which makes patients in the low-risk group unsuitable for immunotherapy.

This methodological drawback may be significant particularly in clinical practice as threshold changes are commonly encountered in disease states such as stroke [ 16 ].

Conversely, some investigations result in scarce amounts of data that may be significant if combined with additional datasets, as long as they are properly preserved.

5 An avoidance of an IOP increase of this magnitude while sleeping may be significant in halting further glaucoma damage in some patients.

Although most of the benefits of SUD treatment are social and economic, the health benefits may be significant enough to offset the costs, at least at the program level.

More importantly, there is not enough research solely using herbal medicine for treating cancer, it may be significant to design well-established study protocols to generate more concrete evidence for the cancer community.

The study found that tobacco PoS density at different proximities from schools was associated with students’ tobacco use, implying that tobacco vendors and advertisements near educational institutions may be significant risk factors for tobacco use among youths 39 .

Finally, given the likelihood for CHO intake to influence variables such as functional recovery and quality of life, the study did not evaluate the long-term results of the patients, which may be significant.

The smaller Vt and lower PIP noted in the post group may imply a lower risk of volutrauma and barotrauma, which may be significant in at-risk populations.

The potential amount of inorganic N released to the soil by a typical colony of 20,000 bees foraging in an area similar to that of the experimental cages (3.24 m 2 ) was estimated at 0.62 to 0.74 g N m −2 month −1 which may be significant at a community scale in terms of soil microbial activity and plant growth.

Consequently, pathologic fibrosis may be significant within orthopaedics contributing to post-operative stiffness and, ultimately, negative patient outcomes.

In addition to PPS, other risk factors such as age, cancer status and gender have been reported to be significant predictors of palliative patient survival in several studies [11] , [14] ._ENREF_18 In our study we did not adjust for other risk factors because though they may be significant predictors of survival for the cohort of patients in our dataset, they may not be in other palliative settings.

Notably, in vitro studies have suggested that cocoa polyphenolic extracts may have neuroprotective effects, which may be significant in neurodegenerative conditions.

Research 21 suggests that there may be significant differences in patients' care preferences when care needs are high, and that policymakers should be flexible in developing resource allocation strategies according to the needs and health status of different groups.

The large numbers of macrophages may be significant; they have been shown to play a part in axonal guidance and synaptogenesis [ 69 ].

OVERALL CONCLUSIONS ON METABOLIC PATHWAYS Taking into account the free energy calculations, SSU rRNA gene data and the relative abundance of functional genes in the metagenome, we conclude that several sulfur redox reactions may be significant in this environment (see Figure 8 ).

Information on patients’ quantitative lung function and need for provocative cardiac testing are not available and may be significant factors determining the time to treat interval.

Hence, the damage caused by PD-L1 inhibitors to cardiomyocytes may be significant.

Site 2, however, may be significant in ensuring that the CaM N lobe is involved in binding to αCaMKII even when site 1 is not filled.

These overlooked interactions may be significant for cellular function: although association constants may not appear optimal, the plentifulness of interacting pairs could force equilibria towards the formation of seemingly unfavored complexes.

There is some evidence from our analysis that this effect may be significant.

That is why acetylcholine leakage at the neuromuscular junction may be significant in the context of thermal imaging [ 3 ].

This may be significant for government authorities and healthcare professionals to protect mental health of people who are affected by the COVID-19 outbreak worldwide.

Anticovid-19 medication therapies; chloroquine, antivirals, and Steroids were also recorded as they may be significant confounding factors.

It is not known whether there may be significant clinical differences in the vascular effects of different ARB or BB drugs in this situation, or whether any benefit is a class effect.