“may be significant”

The rationale for developing a negative allosteric modulator is that there may be significant inhibition of the α7 pathway with a modulator under high states of arousal, such as in anxiety and stress‐related disorders, whereas under basal states, there would be less inhibition.

This alteration is uncommon but may be significant in some particular proteins ( Figure 1C ).

There may be significant inaccuracies in the representation of data for low-income nations as a result of inadequate data collection systems.[ 41 42 ] Several studies also expressed their concerns about using composite indices as reliable tools for guiding national policies on cancer control.[ 43 44 ] There are a number of other annual composite indicators that were not included in this study.[ 45 46 ] In addition, additional research is necessary to validate and refine our predictive model using more precise and up-to-date data in order to provide more accurate cancer outcome estimates.

In asthma, upregulated autophagy contributes to the development of Th2 immune responses and eosinophilic inflammation, while downregulated autophagy may be significant in neutrophilic asthma [ 55 ].

Second, our analysis does not allow for recombination of behavioral variants, cultural exaptation (devising new functions for existing technology), a disproportionate valuing of novelty, or cooperation among innovators, all of which may be significant major sources of cultural diversity [ 5 , 8 , 14 ].

The learning curve may be significant, and procedural safety is likely dependent on thorough preprocedural planning and operator experience. 10 Although spontaneous closure of the left-to-right postprocedural shunt has been reported, 7 in our patient it was still visualized 4 months after the ablation.

This indicates that lncRNA ANRIL may be significant in the advanced stages of endometriosis, possibly influencing the aggressive characteristics of ectopic lesions. lncRNA ANRIL expression showed no correlation with the menstrual cycle phase (secretory vs. proliferative, p > 0.05), as illustrated in Figure 3 and summarized in Table 2 , suggesting th

While CP is carried out at the organizational level, there may be significant individual level drivers, suggesting that decisions around CP might be “...affected by owners' or top managers' characteristics, values and perceptions” (Gao et al., 2017 , p. 278) among other things.

Interactions of NOACs with other drugs are rare, with the exception of a few antibiotics and antifungals, which may be significant for patients with malignancy [ 26 ].

It has to be recognized that side effects associated with oral retinoids may be significant.

These studies provide new ideas for regulating the three potentials and may be significant in clinical treatment.

There may be significant challenges to conducting frailty assessments in clinical drug trials.

Their impact may be significant to patients, families, employers and insurers, if people have to take several days away from normal activities to recover or to care for a sick family member.

It may be significant therefore that the nictitating membrane appears to have a rich arcade of blood vessels.

Since torque values ( q 1, M , q 2, M ) are created by 6 muscles, there may be significant redundancy in possible muscle activation patterns.

Tumor tissue can be obtained by surgery or tissue biopsy, and although the procedure is usually safe, the risks associated with the procedure may be significant, especially in brain cancer [ 17 ].

A correlation between the atmospheric and urinary PAH metabolite concentrations is not consistently observed, suggesting that, in certain occupational settings, exposure routes other than inhalation, such as dermal absorption, may be significant [ 79 ].

For particles with very high LET such as alpha particles, a single event may be significant enough to render the mean absorbed dose misleading, and therefore this formalism may be less accurate for describing radiation damage at the cellular level [ 35 ].

24 The role of lactate may be significant; Sola-Penna 29 argues that lactate may no longer be considered a ‘worthless metabolite’ but ‘a regulatory molecule that modulates the integration of metabolism’ including glucose.

Ground subsidence may follow long periods, and the sinking rate and cumulative effects may be significant.

While minor deviations in one edge may reduce the strength of connectivity between two strongly linked regions, the addition of a connection between two regions which were previously unconnected may be significant in one aggregation method but ignored in another.

This indicates that there may be significant differences in the biochemical profiles of individuals.

Therefore, despite considering subjective factors, such as preoperative anxiety monitoring, our findings indicate that perioperative MAP and changes in heart rate may be significant markers for preoperative anxiety and could predict the severity of perceived pain during cataract surgery.

42 Dose modification of metformin in critical care Metformin has the least impact on basal lactate metabolism within the biguanide class; however, its effect may be significant in situations where other factors disturb the balance between lactate clearance and production. 72 This may occur where tissue hypoperfusion is present.

It is not known whether there may be significant clinical differences in the vascular effects of different ARB or BB drugs in this situation, or whether any benefit is a class effect.