Higher-level interactions may be significant when the main effects and two-way interactions are insignificant.
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“may be significant”
In the literature
Large differences in the distribution of optimal matched regions are observed in the short introns, but some distributions are very peculiar in that they may be significant and deserve to be studied in depth.
Newly trained robotic surgeons may perform few robotic cases during the first months or year following training as this new technique is incorporated into their practice, and there may be significant degradation of skills during this time frame.
Considering that alpha-synuclein aggregates, a key hallmark of the disease, are detected in the ENS earlier than in the Substantia nigra , and non-motor symptoms precede motor symptoms in the course of the disease, a detailed examination of gut microbiota may be significant for the early diagnosis of the disease [ 39 ].
The effect of one locus may be ineffective alone or masked by effects at another locus, but the combined result of several SNPs may be significant.
Although it would reduce costs, not updating the area sampling frame over time causes numerous problems, such as: (1) the area sampling frame may be under- or over-covered at time t n ; (2) the sampled grids at time t 0 may not be suitable for area frame sampling at time t n ; and (3) there may be significant non-sampling errors.
29 In addition, the induction or maintenance of hyperlactemia by LR solution (as suggested by our results) may be significant when larger volumes are infused.
However, its contribution in some cases may be significant [ 60 ]. 4.4.
There is, however, the potential that there may be significant diversity in the included studies in terms of setting, population, disease, and attack rates, so as to not render the data amenable to pooling.
melanogaster revealed that this protein is partly disordered and possesses a unique quaternary structure that may be significant for its regulatory activities.
Thus, changes of the clinical symptoms may be significant if additional follow-up assessments are conducted several months later.
In particular, dietary risk factors may be significant; for example recent analyses suggest that high consumption of red meat might increase risk of T2DM by as much as 30%. 39 Trends in dietary risk factors are difficult to model, requiring repeated high quality dietary data and not available in Turkey.
19 Therefore, the capacity of the subchondral bone to adapt to local mechanical and injurious impacts may be significant in the natural history of OA joint pathology and may have implications for therapeutic interventions.
Nevertheless, while the ICU LOS may be significant during this induction phase, the long-term benefit of stabilising and improving RF function could, in contrast, prevent such patients from recurrent admissions for RVF, volume overload and acute on chronic hypoxic respiratory failure.
can be found at densities exceeding 1 individual per 1 m 3 , the amount of carbon exported from surface water may be significant in jelly fall events, especially considering the immense geographical scale this animal occupies on the planet 9 .
It is worth noting that during the pre-service teacher training process, there may be significant differences in professional identity between the education stage and the initial practice stage.
Univariate Cox regression analysis suggested that the following 10 factors may be significant prognostic factors: age, marital status, T stage, N stage, bone metastasis, brain metastasis, liver metastasis, surgery, chemotherapy, and radiotherapy.
Most children with ASD require a general anaesthetic to successfully carry out a brain MRI exposing them to anaesthesia related risks, and while this risk is minimal in children, it may be significant in toddlers [ 22 ].
However, we are aware of the fact that the number of factors may be significant for the distribution of diseases.
Although there is a growing acceptance by regulatory agencies and commercial vaccine producers that improved vaccine adjuvants are needed to meet the infectious diseases, at present, the safety and regulatory hurdles that will be encountered with the addition of novel immunopotentiators and delivery systems to final vaccine formulations may be significant and are still largely ill defined.
Limitations of the present study are that the bias associated with the D-SHUTTLE dosimeter positions (investigator) and temperature may be significant; in the present study, the temperature was observed to vary from 17 to 19 °C in October 2019, and from 10 to 13 °C in December 2019 40 , 41 .
Although further research is needed, these results imply there may be significant socioeconomic barriers limiting access to organ transplantation for lower income Nepalese patients with end-stage renal disease.
Relevant studies have explained that there may be significant differences between men and women in the correlation between physical activity and heart disease and the benefits of physical activity in reducing the risk of coronary heart disease due to sex-specific factors (including hormones) [ 36 ].
It can be reasonably inferred based on these characteristics that there may be significant differences in the chemical profiles of carbohydrate and amino acid compositions between acacia honey and rape honey [ 6 ].
It is not known whether there may be significant clinical differences in the vascular effects of different ARB or BB drugs in this situation, or whether any benefit is a class effect.