“may be significant”

In contrast to the preservation of submucosal ganglion cells on rectal biopsies, there may be significant histological changes in the deep layers (observed especially on resection specimens), such as decreased Cajal interstitial cell counts [ 54 , 55 ], decreased myenteric ganglia [ 56 ], decreased density of neural enteral structures [ 57 ] and/or smooth muscle hypertrophy [ 58 ].

Laura Soucek and his colleagues ( Masso-Valles et al., 2020 ) suggested that MYC, MYCL and MYCN might be therapeutic targets for lung cancer and that elevated Myc levels were also associated with treatment resistance, there may be significant opportunities for the combination of Myc inhibitors with immunotherapies.

Childhood emotional abuse and sexual abuse may be significant risk factors for the transition from MDD to BD, while exercise may partly offset the risk effects of emotional abuse and this transition.

This study also highlights another important observation that average GLS value may not truly reflect the early dysfunction seen in regional strain.[ 7 ] As the classic GLS strain value noted in these studies was cumulative data of all segments, a closer observation showed that there may be significant discrepancies in regional strain value between each segment (i.e. overall regional strain of −18% with −30% in apical septal segment but −11.3% in basal and mid inferoseptal segments).

In addition to the financial costs of unemployment which may lead to greater loneliness, there may be significant social costs.

These may be significant.

While the average profile blurs the influence of signal changes along the way through the ionosphere, in single profiles this influence may be significant.

Therefore, we hypothesized that the SLC25A38 protein may be significant in the pathological changes associated with leukemia.

However, even if severe paralysis develops early, there may be significant recovery, making it difficult to predict the prognosis [ 1 ].

The influence of the depth from which specimens are sampled from the joint may be significant [ 30 , 42 , 43 ].

Furthermore, racial differences in completion rates have been neglected, and research with younger adults suggests that there may be significant differences in the completion rates between racial groups.

Limitations of Study The limitations of our study, as well as any retrospective research, are that the presented data were already collected, and it was not possible to include certain variables that may be significant for the therapeutic outcome of TDI.

Furthermore, there may be significant key differences between individuals using metformin who have contact with the secondary health care sector and those who do not, potentially leading to confounding.

The observed variation in this study may be significant in subsequent phases of patient care, such as the postanesthesia care unit, floor, intensive care unit, and after discharge.

This may be significant as South Africans of Asian descent are known to be at high risk of GDM.

We believe this is a novel observation for spectral learning, which may be significant for future algorithmic work in spectral learning.

Naturally, we suspect that there may be significant heterogeneity in Npas4 expression dynamics across the POMC population as well.

The results of the Cox model for the ITT analysis may be significant because it included a higher number of events per treatment group than the primary analysis.

According to network analysis, TNF, GAPDH, IL-6, AKT-1, IL-1B, and VEGFA are prospective therapeutic targets, while osthole, cauloside A, ammidin, angelicone, beta-sitosterol, and asperosaponin VI may be significant active components. 1705 biological processes (BP), 155 molecular functions (MF), and 89 cellular components (CC) were identified by GO analysis.

The role of CEM in B3 lesion management, in situations where the necessity of surgical intervention is still debated, as in the case of atypical ductal hyperplasia [ 23 , 24 ], may be significant: the presence of peri-biopsy enhancement could serve as an indication for surgery [ 25 ].

On the other hand, at concentrations used, there may be significant effects on PKC isoforms, especially PKCε, PKCη and PKCδ activity (IUPHAR drug data base).

14 A previous study also reported that ACL reconstruction improves the MM posterior shift, 37 and the effect of ACL reconstruction may be significant in MM as a large number of concomitant ACL reconstruction cases were included in this study.

Additionally, there may be significant confounding from a variety of other patient and hospital variables that were not collected as a part of this study.

The risk resulting from usage may be significant as the protective effect of the mask designs we have looked at is poor.

28) Rarely, the degree of tracheal compression may be significant, leading to clinical symptoms and resulting in innominate artery compression syndrome. 29) In this condition, further assessment with cross-sectional imaging (CT or MRI) should be performed to delineate associated arch anomalies.