“may be significant”

In addition, it has been reported that innate-immune activation via toll-like receptor 9 (TLR9) may be significant in diabetic renal injuries through the overproduction of glycosylated IgA1, leading to enhanced immune-complex formation and glomerular deposition [ 41 ].

Inflammation and endocrine dysregulation may be significant factors in the development of the sarcopenia ( 53 , 54 ).

Of note, NOX4 is localized along the inner mitochondrial membrane, and the potential interaction between these two sources of ROS may be significant determinants of the total mtROS in the endothelium [ 67 , 68 ].

Min and colleagues showed, as in our study population, that in a clinically selected cohort for intensive chemotherapy, functional tests, such as the gait speed test and the sit and stand speed test may be significant tests for OS prediction.

Although strains may share a common ancestor and sub-lineage, there may be significant point mutations and antigenic changes between evolving strains of the same sub-lineage (e.g., BA.2.12 versus BA.2.12.1), resulting in different antibody cross-neutralization upon infection ( 12 ).

This formerly unrecognized feature may be significant in light of images collected from mating bcd 1 mutant Tetrahymena ( Figure 10 ).

Then, also, pain of a peri- odic character is met with in the persons of those who are the subjects of an ear affection due to malarial poisoning, and in those persons who are overworked and under fed, and who get too little sleep, as students and night watchmen. Pain, therefore, may be significant of disease in the ear or in adjoining parts, or in organs remote from it.

The potential side effects of excessive neurotrophin treatment, as may occur with pump-based systems, is currently unknown, but may be significant since, in addition to neuronal survival and differentiation effects, neurotrophins can also elicit changes in ion channel properties and neurotransmitter release, and are important in modulating activity-dependent neuronal plasticity that is essential for the functional and structural refinement of neuronal circuits [60] , [61] .

Postoperative Care Postoperative Complications While proximal aortic repair is potentially life-saving, there may be significant perioperative morbidity.

In cases of high flow, that is, with minimal diffuse coronary atherosclerosis or microvascular dysfunction, the trans-stenotic gradient may be significant and ≤0.80, yet the maximum achievable flow may still suffice to avoid myocardial ischaemia.

This population could be considered self-selective as only 22% of FSW and 17% of MSM continued taking PrEP up to the third month, and there may be significant differences in risk-compensation between those who continued with PrEP and those who did not.

[ 40 ] offer further support about the central role of NO in root-pathogen interaction, which may be significant to developing novel plant-protection strategies [ 46 ].

This idea is based on the observation that peaks shared with for only few subjects may be noise, whereas peaks shared with more subjects may be significant.

Since TMV 2 and TMV 2-NLM differed subtly at DNA level, the background noise in detecting the marker-trait associations was minimum; therefore, the markers identified in this study for the taxonomic and productivity traits may be significant and useful in peanut molecular breeding.

Thus, there may be significant crosstalk between the different proteostasis systems including autophagy, the UPS, the unfolded protein response in the ER, the heat-shock response and other quality control mechanisms [ 95 ].

Considering the developmental phenotype observed in previous studies, we propose that in P300 knockdown embryos at the late 8-cell stage, the dysregulation of genes associated with embryonic development and the failure of tight junction assembly events may be significant reasons for embryo failure to transit from the 8-cell to the morula stage.

protegens AS15 contain genes related to biocontrol traits (i.e., siderophore, polyketide, phosphate solubilization, motility, and biofilm formation) that may be significant factors in the host colonization and protection against pathogenic infections ( 7 – 10 ).

The limited availability of IgG for dengue in our data may be significant because multiple studies suggest that secondary and concomitant infections with several serotypes could lead to more severe manifestations of the disease [ 33 , 35 , 36 ].

Li and Wang [ 46 ] showed in a large observational study that PD patients required lower doses of ESAs to reach target hemoglobin levels, which may be significant considering the emerging safety concerns.

It may be significant that the camE 25-1 and camE 25-2 genes are located on opposite strands of the CAM plasmid [ 4 ], and consequently may possibly be divergently transcribed, although this was not evident from a recent study of transcriptional control of the CAM plasmid-coded enzymes [ 59 ].

[ 29 ] suggests that diastolic blood pressure control may be significant among CKD patients, potentially due to underlying pathophysiological differences related to vascular stiffness and volume status.

Based on the above studies, it can be concluded that physical disability, fatigue and self-efficacy may be significant predictors of MS patients’ acceptance of illness and the physical and mental aspects of HRQoL.

Is presynaptic A 1 R‐adenosine signaling also involved in regulating glutamate release in all of these projections? It may be significant that while plasticity becomes gated at mature TC synapses, cortico‐cortical synapses remain plastic after critical periods close (Amitai, 2001 ; Froemke et al., 2007 ; Jiang et al., 2007 ; Oswald and Reyes, 2008 , 2011 ; Huang et al., 2012 ), suggesting different regulatory mechanisms for TC and CC projections.

13 reflect Golgi stack dynamics that may be significant for basic cell physiologic and pathologic processes and help to learn, how cells respond to conditions of stress.

Inactivation of Notch signaling and expression of ASCL1 may be significant for SCLC carcinogenesis.