“may be significant”

In India, where there is a genetic predisposition to IR and cardiovascular risk, this impact may be significant.[ 5 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ] IR plays a key role in the pathogenesis of the metabolic syndrome and is frequently detected among HIV patients on ART.[ 22 , 23 , 24 ] Biochemistry of IR: pancreatic b-cells release insulin in response to hyperglycemia, stimulating muscle and adipose tissue to store sugar, and blocking the liver from releasing glucose into circulation.

Of course, although the interactions may be significant, caution should exercised when interpreting their complexity until replicated.

It may be significant that tendon reflexes disappear-perhaps an indication of nerve involvement-and there are recorded examples of diminished peripheral sensation (Berg, 1951).

First, although the core function of clock genes in stabilizing the cell cycle is generally conserved across non-mammalian models, there may be significant differences in the details of regulatory mechanisms.

Our major findings were as follows: (1) age, haemoglobin, globulin, and creatinine may be significant predictive factors for renal dysfunction in patients with SRCs, and the cut-off values for haemoglobin, globulin, and creatinine were 135 g/L, 27.2 g/L, and 85 μmol/L, respectively, and (2) the predictable nomogram is accurate and stable, with AUCs of 0.829, 0.752, and 0.888 in the training cohort, internal and external validation cohorts, respectively.

Although this effect affects LAA% and cluster analysis, the impact may be significant on cluster analysis because effacement of thin connections between LAA that may occur by using a lower threshold results in substantial underestimation of sizes of LA clusters.

However, self‐reported mentalizing was associated with reduced peer problems; therefore, adolescents' perceptions of their own mentalizing skills may be significant in understanding how and why some adolescents encounter negative peer experiences.

EGFR amplification/mutation and mTOR mutations may be significant resistance mechanisms associated with BRAF-targeted therapy, as signalling through the EGFR/PI3K/AKT/mTOR cascade overcomes the block on BRAF/MEK to continue cell proliferation. 116 This phenomenon should be explored further to identify the specific subsets of BRAF -mutant glioblastoma patients that may benefit from BRAF/MEK therapy alone and to clarify whether the addition of EGFR or mTOR inhibitors is required for BRAF-resistant tumours.

This preference may be significant for DNA repair in vivo .

We took single measurements by a single operator, and even slight variations may be significant as the changes in ONSD were so small.

The aim of the present study was to explore the biological behaviors of human VM endothelial cells and their responses to rapamycin, which may be significant in the design of effective strategies for human VM treatment.

As age is positively correlated with circulating AGEs ( 11 ) and negatively with kidney function ( 51 ), a decade difference may be significant for the AGEs' pool due to both higher accumulation and decreased disposal.

[ 22 ] Closeness of contact and social factors may be significant.

Peripheral blood NK lymphocytes could reflect local immune system conditions at the maternal–fetal interface and may be significant for reproduction.

Even though microplastic-associated animals are rare and less diverse when compared to those associated with macroplastics [28] – [38] , ecological implications of this phenomenon may be significant (e.g.

Whereas two decoders may both predict MC movement parameters equally well, there may be significant variability in the parameters assigned to a specific neuron [33] .

Till now the stereoselective biotransformation of ALO and their effect on ALO quantities in plasma is not known in published literature. Conclusion There may be significant variability between the enantiomers of chiral drugs in terms of their pharmacokinetics, efficacy, receptor affinity and toxicity.

There may be significant differences in the age distribution, gender ratio, racial composition, and smoking habits (such as smoking duration and daily smoking quantity) among different studies.

Although the clinical effects of bedtime on BP may not be significant in all populations, these effects may be significant in some special populations.

22–25 Thus, effective diagnosis and treatment of BV may be significant for reducing the perinatal infection rate.

Additional mammalian reservoirs such as chipmunks and shrews may be significant hosts for immature ticks and may be pathogen reservoirs in certain locations, a belief speculated to have contributed to the failure of some white-footed mouse treatment schemes [ 27 ].

These pharmacokinetic comparison results suggest that there may be significant pharmacokinetic differences between methotrexate-loaded nanoparticles and nanoemulsions. 3.2.

It is particularly crucial to examine DOP production in coastal systems because the lateral supply of DOP from continental margins to the ocean gyres may be significant.

Notably there may be significant differences in prognosis among tumors of different pathological types.

Inactivation of Notch signaling and expression of ASCL1 may be significant for SCLC carcinogenesis.