“may be significant”

This distinct niche organization is maintained throughout the course of kidney development, suggesting it may be significant for proper nephrogenesis.

Despite distinct mechanisms of drug action, there may be significant cross-resistance between abiraterone and enzalutamide [ 41 , 42 ].

The nature of the nodes is more readily seen in Figs. 4-6, in which it is apparent that they arise from the presence of electron-opaque material between the central regions of the more distal cisternae. The nodes display a superficial resemblance to the grana of chloroplasts. The distribution of the intercisternal material across the parabasal body may be significant from a functional point of view, as will be indicated later, and will, therefore, be described in some detail.

Maintenance of HSC quiescence by dmPGE 2 may be significant for protection, since the portion of HSCs in active cell cycle is less capable of reconstitution upon transplant into the lethally irradiated environment compared with those in G 0 /G 1 ( Fleming et al., 1993 ).

Because PC2 was positively correlated with the expression of CDH1 , S100P , and RAB25 , these genes may be significant in the classification of the four subtypes.

It may be significant that this group was also the only group to exhibit a significantly reduced RI at GD 15.

In conclusion, TS induces changes in the content of secondary metabolites through regulating genes expression in the phenylpropanoid biosynthesis pathway, and these secondary metabolism changes may be significant in improving the response and adaptation of maize radicles to low temperatures. 3.6.

Combined with the higher rates of overall healthcare utilization for the ADHD group found here, these results suggest that the incremental costs related to ADHD in Japan may be significant, as was reported in a literature review for the United States [ 12 ].

The elevated levels of PVC microplastic particles found in this study suggest that industrial waste and fishing vessels may be significant contributors to microplastic pollution in the marine environment.

Interestingly, the top 20 drug hits among the three approaches have little overlap, although some drugs may be significant in multiple approaches.

Therefore, there may be significant delays to the initiation of endovascular therapy due to inter-hospital transfer times, especially for patients with basilar artery occlusion who often require intubation before endovascular therapy can be performed.

It has been observed that, using this kind of methodology, there may be significant overestimation of actual use and understanding of labels [ 24 ].

The effects of increasing the amount of apposition at individual synapses is currently unknown, but previous research suggests that the amount of surround is not correlated to synapse size (Ventura and Harris, 1999 ) and that any amount of synaptic contact may be significant (Witcher et al., 2007 ).

Similarly, the risk of injury from long‐term alcohol may be significant in one group, whereas the CVD may cause major disease burden in the other group.

However, when using dedicated brain PET images or particularly dynamic PET images with arterial blood sampling at multiple time points for the absolute quantification of regional metabolic rates, regional differences lower than 10% may be significant.

Remarkably, different levels and combinations of inflammatory signaling molecules can elicit opposing responses, suggesting that context may be significant.

In this area, the internal abdominal oblique is subcutaneous; however, variations in the attachments and the extent of development of the fleshy part of the muscle may be significant.

The potential benefits in terms of convenience for individuals living in rural areas may be significant because they have longer distance to travel to the closest pharmacy when compared to those living in cities and towns.

2 This may be significant in international travel if the patient encounters circadian rhythm disruption and other stressors that result in sleep disturbance.

Considering that there may be significant differences in the nutritional status and the inflammatory status between patients with early-stage and middle-advanced lung cancer, Cox regression analysis was performed for patients with stage I–II and stage III NSCLC in order to further evaluate the potential prognostic value of FAR, SII, and AAPR in patients with different stages of the disease.

However, unlike other bats that have been reported, the great evening bat ( Ia io ) had a higher abundance of Firmicutes than Proteobacteria, suggesting that there may be significant differences in gut microbiota between bats [ 19 ].

Their conceptual review highlights that these benefits may be significant when implemented before significant neurodegeneration occurs.

Numerous clinical studies on detecting ICG in living patients indicate that this finding may be significant in determining the mechanism and circumstances of death [ 5 – 15 ].

They should increase the precision of IOP retrieval in different marine environments, where there may be significant changes in the optical properties of various components of seawater, and where, for example, the assumption of the constant/invariant shape of the spectral absorption coefficient of phytoplankton should be avoided.

Inactivation of Notch signaling and expression of ASCL1 may be significant for SCLC carcinogenesis.