“may be significant”

coli , mortality may be significant ( Halvorson, 2009 ).

The fact that pain wakes patients from their sleep may be significant for metastatic bone disease. 17 , 18 Approximately 25% of the lesions are painless and may be identified via bone and radiological screening. 1 , 19 Consistent with the literature, the most common causes of admission among our patients were pain and pathological fractures.

This may be significant, especially in the situation of the increasing availability of modern therapies, such as cystic fibrosis transmembrane conductance regulator (CFTR) modulators, which have had a positive impact on patients’ functioning [ 13 – 15 ].

Since the ERK pathway appears critical for optimal proliferation in MCF-7 cells ( Hermanto et al , 2000 ), the potentiation of its activation by PTHRP may be significant and could provide a further explanation for the enhanced mitogenesis in cells overexpressing the PTHRP-R.

However oceanic nonlinearities may be significant in the western Pacific.

The results of the present study demonstrated that overexpression of miR-654-3p could inhibit the activation of PI3K/AKT pathways, and targeting the miR-654-3p/QPRT/PI3K/AKT axis may be significant to overcome the problem of DDP resistance.

However, if populations vary in their usage of the target medium (eg, Twitter), prediction accuracy can vary, and this variation may be significant.

6 There may be significant gains from specialization in in-center hemodialysis and unless there is a critical mass of patients using the other modalities, it is not worthwhile to provide them on a significant scale.

This difference may be significant in the larger study.

The use of DWI and the b800/b0 ratio as a new parameter showed an observational difference with high values in GBC that perhaps may be significant in larger sample size.

Notwithstanding radiographic appearances, the physiological effects may be significant.

This effect may be significant in those who already have pathologies in lower limbs; further investigations on this topic are warranted.

Although we have not been able to measure them, we can assume that there may be significant indirect costs associated with endometriosis in Hungary [ 33 ].

The number of particles lost through pores may be significant; consequently, the resulting size distribution might not represent the actual distribution of particles in the sample.

The involvement of Helicobacter bilis infection may be significant in biliary tract malignancies [ 48 ].

However, there may be significant differences between different industries and regions, resulting in different influencing factors, so the conclusions obtained in this study may not be fully applicable.

Thus, environmental conditions may be significant determinants of their existence.

Thus, aberrant modulation of BK Ca channels by AMPK may be significant in a variety of disorders where BK Ca channel dysfunction has been implicated, such as hypertension ( 30 , 34 ), incontinence ( 35 ), ataxia ( 36 ), and epilepsy ( 20 ).

Based on the findings of previous studies, distinct patterns in beta and gamma EEG activity in patients with IGD may be significant neurophysiological markers of IGD.

Given that NAD + , guanosine and deoxyinosine may be significant components of ceAF that may mimic the anti-inflammatory capacity of ceAF, we first conducted in vitro studies using CCK8 assays in two cell lines, including the human lung epithelial cell line (BEAS-2B) and the mouse macrophage (RAW264.7) cell lines, to identify the optimal doses ( Fig. 5A, B ).

Although our study did not analyze epigenetic influences, it is important to note that certain post-translational modifications may be significant in the mechanism of discordant CHD development in MC twins.

NoV transmission via contaminated surfaces may be significant for the spread of viruses.

However, the collective number of patients seen across most of the United States may be significant, with different institutions having slightly different practices.

The large proportion of dangerously high SI values among NASG uses suggests that late recognition and response to OH may be significant factors in Northern Province.

Inactivation of Notch signaling and expression of ASCL1 may be significant for SCLC carcinogenesis.