Barely Significant
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“may be significant”

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In the literature

An intensity-based OTSU segmentation identified the shape of the lobe which was assumed to represent the position of the Glisson capsule ( Figure 2 C, red) that generally encapsulates the whole lobe: In a mathematical model on the scale of a lobe, the mechanical impact of the Glisson capsule (E(Capsule) ≈ 400 kPa, ( Carter et al., 2000 )) may be significant and thus must be taken into account.
However, the risks of non-treatment in affected individuals may be significant; the most severe long-term complication of untreated severe FMF is systemic amyloidosis, typically affecting the kidneys and sometimes the adrenals, intestine, spleen, lung, heart, and thyroid [ 62 ].
Periodic fever syndromes: beyond the single gene paradigm.
Pediatr Rheumatol Online J · 2019 · PMC6515597
Because this is many orders of magnitude larger than the rate of the H-shifts, or of bimolecular reactions with trace gases, the lack of interest in the specifics of the O 2 addition reaction is understandable. However, there are some notable cases for which the exact kinetics of the O 2 + alkyl reaction may be significant.