Barely Significant
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“may be significant”

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In the literature

It should be noted, however, that the prediction did not account for uncertainties in farming practices over the next 80 years, including changes in flora, emergence of competing fungi, treatment options, consumer behaviour, farm management, economy, demography, or landscape, which may be significant.
Conclusions In patients with acute ischaemic stroke due to LVO without evidence of AF and intracardiac thrombi and no competing aetiologies, cardiac CT imaging findings of left ventricular dilatation, visible interatrial shunting, aortic and mitral valve implants, post-ischaemic myocardial scarring and atheroma of the aortic arch > grade II may be significant risk factors for a cardioembolic stroke aetiology.
This result could be interpreted as a manifestation of cellular heterogeneity of distribution of the pentose cycle, possibly reflecting the increased utilization of NADPH by cells actively engaged in lipid synthesis. Recent experiments have suggested that in addition to the pentose cycle, mitochondrial generation of NADPH may be significant in some situations.
Intermediary metabolism of the lung.
Environ Health Perspect · 1984 · PMC1568362