“may be significant”

While the majority of immune studies focus on the role of neutrophils in chronic infection and inflammation in CF, recent studies have revealed that macrophages, which comprise 90% of immune cells in steady-state airways, may be significant drivers of lung inflammation.

For risk avoidance and other reasons, there may be significant differences in the acquisition of innovative resources between state-owned enterprises and private enterprises in actual production and operation.

It may be significant that the lack of ASI residues in full-length ASI(−)RyR1 reduces the efficacy of 10 nM β 1a -mediated activation.

The role of international organizations and donors like International Organization for Migration (IOM), World Food Programme (WFP), and World Health Organization (WHO) may be significant as they will support the idea of inclusive humanitarian policies, fund pilot projects (e.g., voucher schemes or community-based food banks), and initiate bilateral collaboration between Bangladesh and a host country regarding emergency preparedness and response.

As stated above, the family Lachnospiraceae may be linked to environmental factors and is known to be able to protect against human colon cancer by producing butyric acid [ 59 ], therefore, our findings on Lachnospiraceae may be significant.

A potential mechanism contributing to cognitive dysfunction in both insulin-insensitive and insulin-insufficient disorders may be significant sustained glucocorticoid elevation [ 87 ], a sex-independent finding we previously reported in this model (200–300 % elevations in corticosterone were observed in both HFD females and males) [ 1 ].

Our findings may be significant, as compounds that modulate membrane excitability may have disease‐modifying properties.

Thus, in both these configurations dimerization seems to be of little importance, although we anticipate that in other configurations the effects may be significant.

It should be emphasized that rs2200733T and rs10033464T variants are frequently present in white populations (∼40% of people) and therefore studies of their role in cardiac arrhythmia may be significant for a vast number of patients.

This reciprocal interaction suggests that the balance between NF-κB-driven inflammation and PPAR-α-mediated mitochondrial lipid oxidation may be significant for the progression from metabolic stress to endothelial dysfunction and the consequent cardiorenal injury.

8 The authors concluded that globally it seems that there may be significant differences in the FeNO measurements carried out with different instruments especially if from different manufacturers; this must be kept in mind in clinical practice and in the evaluation of studies especially in relation to the normal cut-offs considered.

The results may be significant for evaluation of the condition of the White Stork population.

This relationship may be significant, as mAbs against α4β7 protect against transmission.

However, without treatment existent infections will remain, the pathophysiological implications of which may be significant on small ruminant health if nutritional availability is likewise depressed.

pyogenes , 24 which may be significant considering that separate studies have demonstrated that M. catarrhalis potentiates the adhesion of S. pyogenes to the nasopharyngeal epithelium. 25 , 26 Other bacteria cultured from patients with pharyngitis include Haemophilus influenza , 27 Arcanobacterium haemolyticum 28 and the opportunistic

Although the temperature changes, and in particular for mutant V871A, are subtle, in the context of a disease the onset of which may occur over a long period of time, the observed subtle changes in T m for these mutants may be significant.

scaly lesions on the edges and palmar aspects of the hands, greyish discolouration of the ear pinna and stiff and hard helical cartilage were noted in our patient can easily be missed.[ 6 ] Calcifications in the coronaries, cardiac valves and aortic root, urinary pigment calculi and nephrotoxicity may be significant enough to alter anaesthetic management.[ 2 ] Although surgical implications are minimal, surgeons should involve the anaesthesiologist, physician and cardiologist early in the pre-operative period to establish a well-planned management approach.

Since there may be significant differences in patients' perceptions of the quality and quantity of information received and in their participation in medical decisions among populations in different countries, it is important that studies like this should be conducted in Brazil. 17 OBJECTIVE The purpose of this study was to evaluate Brazilian CML patients' perceptions about the disease, their access to information regarding the diagnosis, treatment and care received, adverse effects and relationships with doctors; and associations of these variables with patients' demographics, region and access to healthcare.

It may be significant that this only existed as a unique sequence in a congenital sample.

There may be significant bottlenecks in access to MRI in non‐academic settings and countries besides the United States, 39 and therefore it might influence the door‐to‐needle time for ATTs.

The data for CXCL9 may be significant, as apoE can suppress T‐cell levels (Kelly et al . 1994 ; Mistry et al . 1995 ) and there is an age‐ and APOE ‐dependent decrease in Aβ‐specific CD4 + T‐cell activity in humans (Begum et al . 2014 ).

Furthermore, a significant correlation between histopathological findings and ranavirus infection was not found in these populations [ 69 ]; however, the observed renal tubular changes may be significant given that ranaviruses are thought to target renal tubular epithelial cells [ 56 , 68 , 85 , 90 , 96 ].

Moreover, there may be significant variations in prevalence estimates due to country-specific differences in survey field settings, such as sampling, quality control and the level of interviewer training.

We concentrated on validating the most frequent fusions because they were found in numerous tissues, which could indicate that they play a part in some fundamental function that may be significant for all cell types.

Thus, cannabis‐induced psychosis‐like effects may be significant in the early detection of psychosis.