Barely Significant
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“may be significant”

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In the literature

The increased stability of the 1, N 2 -εdG lesion in the absence of the complementary dC correlates with the one-base deletion extension product observed during the bypass of the 1, N 2 -εdG lesion by the Dpo4 polymerase, suggesting that stabilization of this bulged intermediate may be significant with regard to the biological processing of the lesion.
Our results suggest that target derepression may be significant even if the competitor is in low copy numbers, provided a certain heterogeneity in kinetic parameters (e.g. for a catalytically degraded target and a stoichiometrically degraded competitor) is present, in line with recent experiments pointing to a key role of parameter diverseness [ 36 ].