“likely to be significant”

Although the per-incident cost for an inpatient ADE can exceed US$3000, the economic impact of outpatient ADEs is also likely to be significant [ 6 ].

As these differences in the ECM landscape are likely to be significant, this raises the possibility of using their changes in expression levels as circulating biomarkers of HF diagnosis and severity. 1.5.

However, at the population level, the R1047L variant impact is likely to be significant given its common nature, increasing risk to a small degree in many people.

However, these aforementioned factors are hard to change and the identification of factors that could be altered, for example by varying the diet, is likely to be significant for the prevention of asthenozoospermia.

Because of data scarcity, post‐assimilation parameter and predictive uncertainties are likely to be significant.

The mutations detected in this study were likely to be significant because they were not observed in otherwise healthy subjects.

14 The cost of DCM to society has not been measured yet, but it is likely to be significant.

20 Although shorter TPT regimens – isoniazid and rifampicin once daily for 3 months (3HR) – have been found efficacious with reportedly higher adherence rates compared to 6 months of daily isoniazid, 21 , 22 our findings suggest that the effect of shorter regimens on preferences is only likely to be significant if combined with fewer clinic visits.

One implication of the species variability in DNA methylation patterns in the blastocyst is that there is likely to be significant differences between species in the genes that are differentially regulated between ICM and TE.

cholerae identified here are still likely to be significant within the context of human health.

In the clinic, initiating and modifying therapeutic intervention based on MRI metrics require knowledge of when an observed change in an MRI parameter(s) is likely to be significant.

Although clearly requiring investigation in human embryos, such processes are likely to be significant regulators of successful embryogenesis and allow for the integration of MT data with the detrimental effects of Bmal1 knockdown on embryogenesis.

However, the protected animals from group 2 and 4 had also the highest total antibody levels and therefore we conclude that in the case of a rabies-based EBOV vaccine, high level of GP-specific antibodies that are IgG1-bias are very likely to be significant as shown for groups 2 and 4 in Figure 6B .

We asked if principal components that account individually for small fractions of variation in the data are likely to be significant.

Extra cost is more likely to be significant and prevalent for households with moderate to severe disability, as opposed to those of slight to severe.

Clustering of top-scoring sites in a group of related genes is likely to be significant when it arises from an unbiased genome-wide analysis. miR-7 and miR-2 were selected for target validation. miR-7 Regulates Notch Targets Among the top 10 predictions for miR-7 , we found Enhancer of split ( E(spl) ) and Bearded ( Brd ) complex genes ( Figure 3 A).

At elevated C0–C2 concentrations, competition between sites, cooperative interactions, and steric hindrance are all likely to be significant.

35 There are also longer-term needs among those surviving COVID-19, such as rehabilitation and palliative care, which are likely to be significant and important for service planning but were not modelled here.

Even after adjustment for SBA attendance or place of delivery, settlement and ethnicity were still likely to be significant factors.

The study involved 8 different experimental runs for 4 chosen factors likely to be significant at low (-1) and high (+ 1) coded levels, as given in Table 1 .

Interestingly, we found that when the sham was credible, the results were more likely to be significant than when the sham lacked credibility.

There are likely to be significant mechanistic differences to explain body composition abnormalities in these groups with implications for the development of anabolic agents and the identification of patient phenotypes that respond best to them. 28 In summary, although the prevalence of cachexia and pre‐cachexia in outpatients with stable COPD is low, these phenotypes are associated with important clinical manifestations including poorer exercise tolerance and greater respiratory disability.

The resulting impacts on animal populations are likely to be significant at both regional and global scales [3] , [4] , [5] , [6] , [7] , [8] , [9] .

This is likely to be significant for many neural systems in which timing is critical, such as motor responses, and is a factor that needs to be considered when interpreting dynamic neural responses.

This is likely to be significant as social traits are thought to be important in determining both the virulence and persistence of pathogenic microbial infections [29] , [30] , [31] .