“likely to be significant”

Given that fold change is a component of the p-values generated by Agilent and Rosetta data analysis software, the overall effect of fold change on data correlation is likely to be significant as shown in Figure 4 .

Politics Finally, there is likely to be significant political push back about mandate-driven efforts to address health inequity, in particular from conservative and libertarian groups committed to the use of market principles.

Here, participants highlighted variations in school contexts as likely to be significant in multiple ways to the delivery of a WSA, suggesting that these be captured in reviewing existing practice and mapping needs to understand more about existing activities and school populations.

The bias decreases as the true treatment effect size μ increases, which aligns with existing literature [ 7 , 12 , 18 ] and prior exploratory analysis [ 35 ]; as treatment effect increases, results are more likely to be significant and are thus less prone to ORB.

In clinical practice, the effect of aspirin on HbA1c is likely to be significant only when large doses are administered over a long period of time.

It's important to add that the chosen modulation index is more likely to be significant in neurons with higher firing rates (Figure S8).

Clinical Relevance The implications of our findings are likely to be significant in forming a risk assessment tool for those who are admitted to hospital with COVID-19 and who may require more intense monitoring and/or escalation of treatment at an earlier stage.

However, the return rate for the survey was only 2.1% with responder bias likely to be significant.

We note that there is likely to be significant improvement possible from a more advanced or more optimized set of primitives; we did not iterate on the selection in this work.

In addition, MCSCs are promising triplet sensitizers for photon upconversion or reactive oxygen species generation, for which MCSC composition and site-dependent regulatory mechanisms are likely to be significant.

32 Reported P-values for correlation coefficients (Pearson and Spearman rank) were uncorrected for multiple comparisons because of the strong prior evidence (based on the original English version) on which correlations were likely to be significant.

The impact of our results for these ecosystems is likely to be significant, but due to the complex feedbacks mentioned in these relationships, it is difficult to know without extending the model and further empirical data on the strength of these feedbacks.

However, the effect is likely to be significant in the case of piped sources with discontinuous service that encourage users to store water in the home.

Finally, there is likely to be significant interplay between psychological status and dyspnoea.

Existing published data support the observation that biting midges are likely to be significant vectors compared to mosquitoes, which are comparatively incompetent.

As the difference in GAG content between NP and AF is large, the Donnan potential between these two neighboring tissues is likely to be significant.

There is also likely to be significant reduction in the availability of face-to-face Careers Information Advice and Guidance (CIAG) for some client groups.

In cases where loss of suitable habitat is likely to be significant, it is possible that these chimpanzees may be able to compensate and remain in their degrading habitat.

However, it is clear that multiply hydrogen bonded triples, which consist of at least two hydrogen bonding interactions per base, will be especially stable and the structural conservation of such triples is therefore likely to be significant.

Microglia are likely to be significant producers of Aβ-containing EVs post TBI as well given their known role in the clearance of Aβ (Ries and Sastre, 2016).

If there is significant cell death, estimated indirectly in surviving children by the burden of diffusion restriction seen in brain magnetic resonance imaging, there is likely to be significant neurologic sequelae from injury [ 15 , 16 ].

genetics GWAS human multi‐omics sample size transcriptomics National Institute on Alcohol Abuse and Alcoholism 10.13039/100000027 R21AA027827 National Institute on Drug Abuse 10.13039/100000026 DA54750 K02DA32573 R01DA054750 R01DA054869 R33DA047527 T32DA007261 U01DA055367 For gene prioritization (i.e., genes that are proximal to GWAS significant loci in the smaller GWAS; Figure 2 ), genes that were identified both by proximity to a genome‐wide significant locus and by multi‐omics were more likely to be significant in the larger GWAS than genes only identified by a genome‐wide significant locus (Figure 2A ).

We have provided a new R package, interactionFPIR, to estimate the values of M and N , and suggest using FPIR whenever the interaction term is likely to be significant. • Introduced fractional-power interaction regression (FPIR) as Y ~ β 0 + β 1 X 1 + β 2 X 2 + β 3 X 1 M X 2 N + ɛ to replace the current regression model Y ~ β 0 + β 1 X 1 + β 2 X 2 + β 3 X 1 X 2 + ɛ; • Clarified the rationale of FPIR, and compared it with regular regression model, polynomial regression, generalized additive model, and random forest using regression models for 4692 species; • Provided an R package, interactionFPIR, to calculate the values of M and N , and other model parameters.

Notably, in individuals diagnosed earlier in the epidemic and withheld ART for some time or individuals with poor ART adherence, we predict that the level of adaptation is likely to be significant, particularly in the proteins Gag and Nef [ 30 ].

48 For Hong Kong, the actual impact from spatial variation is likely minimal given the geographical compactness of this city (1106 km 2 , the fourth most densely populated area in the world) and its efficient transport network. However, temporal variation is likely to be significant given the recent advances in communication technology and the high saturation of smartphone usage in Hong Kong.