“likely to be significant”

Inherent geographical, economic, and social challenges experienced by rural residents are likely to be significant factors that shape the availability of opportunities to maintain an active lifestyle, compared with those living in urban settings ( 37 – 39 ).

These are the patients in whom the consequences of treatment with an antibiotic ineffective against the pathogen causing the exacerbation are likely to be significant, with clinical failures, hospitalizations and early recurrences likely.

As indicated by Hunter et al., there are likely to be significant differences in resistance mechanisms between trastuzumab and TDM-1, given the pre-eminence of the DM-1-mediated effects of the ADC [ 219 ].

Over an 11 year period, there are likely to be significant population changes.

Thus, this limitation is less likely to be significant in our results.

There is also likely to be significant publication bias present, as organisations with higher levels of funding and better outcomes will have the resources to publish their results.

Several of the defects we identified, such as gaps in the follicle epithelium and the lack of an interfollicular stalk, are incompatible with follicle development and thus likely to be significant causes of reduced fecundity in aged flies.

Many processes involving GTPase signaling are associated with Ca 2+ transients and Ca 2+ -regulated kinase activity [ 54 , 58 ], and we speculate that CDPK-mediated membrane recruitment of ROP GTPases is likely to be significant to a wide range of cellular processes in plant cells. 4.

The contribution of these services to families’ out-of-pocket health expenses is likely to be significant; the mean price of a birth (either vaginal or C-section) as measured on the 2008 DHS was four times higher in private compared to public facilities [ 17 ].

These incentives are likely to be significant factors for users.

To further establish the specificity of the associations between the AES profile and metabolites, we also examined whether these associations were more likely to be significant than associations between metabolomic markers and any other possible score made out of five other IDS items that did not belong to AES (see Supplementary Methods for details).

Neural xanthophyll content in primates varies greatly among individuals, and genetic factors are likely to be significant contributors.

However, given the high frequency of cell division in developing organisms and in adult humans, the occurrence of DSBs in mitosis is likely to be significant.

Once again the differences in treatment populations are likely to be significant contributors to discrepancies between studies as patients with secondary immunodeficiencies are likely to be older and to have more comorbidities.

In the development of such devices with 2D materials as active components, surface forces are likely to be significant because of the large surface to volume ratio of these materials.

The logistical problems associated with the allocation process are likely to be significant factors in the relatively low rate of adoption of minimization.

Fourthly, due to the contextualised nature of the findings and because the present study focused on cardiac ICUs from selected hospitals in Iraq, there is likely to be significant limitations to the transferability of the qualitative results to different clinical environments or health care systems. 6.

The biases for all NHP were smaller and less likely to be significant when reaching for the target.

Second, we assessed with meta-regression analysis whether crude RR estimates calculated from the available data were less likely to be significant than those provided directly in the paper.

The observation that FNIR-Tag antibody conjugates are less subject to hepatobiliary uptake is likely to be significant utility, particularly in instances that seek to visualize biological processes in this region.

If the biosensor malfunctions or if the drug leaks then the repercussions are far more likely to be significant in terms of having a negative impact on the everyday cyborg's health.

However, the impact of khat use on mental illness is likely to be significant [ 21 ].

The effect of background curvature is more likely to be significant for samples of high mean atomic number, since the continuum intensity is then greatest, and a given degree of curvature has a greater effect in terms of elemental concentration.

The differences in the baseline, such as age or gender, are likely to be significant factors contributing to the results.

Thus, does TXA 2 signaling condition the metastatic niche to create a more nurturing environment? The effects of TP on cancer-associated fibroblasts have not been investigated; however, they are likely to be significant given the emerging role of these cells and TXA 2 signaling in tumor progression.