In comparing the change in treatment effect by year, facilitator enthusiasm and objectives met improved from year 1 to 2 in the intervention group (classroom control was just beyond significance when adjusted, FDR p = .052).
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The same held true for ODD, with the exception of one time point, from age 6 to 8 ( β = −0.10 , p = 0.028), but this path was rendered just beyond significance when adjusting for the false discovery rate ( p = 0.052) Regarding teacher report, increased symptoms of CD predicted reduced social skills from age 6 to 8 years ( β = −0.16 , p = 0.001) only, while increased symptoms of ODD predicted reduced social skills from age 8 to 10 years ( β = −0.12 , p = 0.015) only.
Eosinophils also trended higher in RAGE TG mice compared to controls; however, the average increase was just beyond significance (p =0.06).
The top functional categories were membranes (GO:0016020) and calcium ion transmembrane transport (GO:0070588) both with p = 0.069 just beyond significance following multiple test correction.
mutans lay just beyond significance with a P value of 0.064, suggesting that a degree of preferential binding to S . mutans using the galactosylated ligand (5) Gal could be achieved.
Although lycopene mitigated mitochondrial quality control disorder via regulating the SIRT1/PINK1/mitophagy axis and the mitochondrial unfolded protein response [ 89 ], the positive correlation of the intake of lycopene with the expression of PINK1 was just beyond significance.
Moreover, this effect was more pronounced in the central region of the cells, near the nucleus (33% increase), and less in the periphery (21% increase), where the effect of GFP-desWT expression was just beyond significance.