“highly significant”

The three large duplications in wMelPop, wMel2_a and wMel2_b were highly significant (t tests: p <10 −20 ).

The ciliary modules were found to share on average more than 50% of genes with each other, this overlap statistically highly significant (P<10 −20 for the least significant pair of the datasets; see Table S4 for details on the cross-dataset overlap of the modules).

It exhibited highly significant associations with multiple musculoskeletal traits, most notably with appendicular lean mass ( p = 1.0 × 10 −20 ), trunk fat-free mass ( p = 1.8 × 10 −8 ), and standing height ( p = 2.0 × 10 −9 ).

[ 5 ], where they demonstrated a highly significant enrichment for genic regions within the group of loci identified as potential targets of positive selection (p < 1E-20).

Each of the three possible pairwise regressions were highly significant with p<10 −20 .

We observed highly significant ( p < 1e−20) enrichment for the GO biological process (BP) term “translation”, GO molecular function (MF) term “structural constituent of ribosome”, and GO cellular compartment (CC) term “ribosome” among GO terms for differentially downregulated genes in external cortical tissues after 3 months of storage.

These overlaps are highly significant (Fisher’s exact test, p<10 −20 ).

As further confirmation of the quality of the model, analysis of variance of cross-validated residuals (CV-ANOVA) for the PLS-DA model was highly significant (p<1x10 -20 ).

This effect is strongest for the pairwise deviation between means (61% reduction), but also highly significant for the other measures ( P < 10 −20 in all cases).

Most notably, we observe a highly significant dysregulation of WNT11 →FZD1, WNT11 →FZD3 and WNT11 →FZD7 in stage II ( P -value < 10 − 20 ), as well as of WNT11 →FZD7 in stages I and II.

Two highly significant loci mapped to chromosome 17 and chromosome 4 After the Hardy-Weinberg equilibrium test (Fisher’s exact test, P -value > 10 −20 ), 15,092,493 biallelic SNPs on all 29 autosomes remained for the GWAS.

Fourth, there is a highly significant enrichment for extreme iHS values in genic regions ( p < 10 −20 in all populations; Table S1 ).

Among them, the pink, purple, yellow, and turquoise modules were highly correlated with the 2-cell to morula stages ( Supplementary Figures S3A,B ), and the correlation was highly significant based on the p value ( p < 10 –20 ).

GO overrepresentation within the 531 gene cluster 7 (macronuclear G1/S, late micronuclear S) showed a highly significant enrichment for processes linked with S phase, including DNA replication ( P = 1.00E-20), DNA repair ( P = 1.03E-18), regulation of the G1/S transition ( P = 0.04), and histone modifiers ( P = 3.36E-3) ( Figure 6B ; Supplemental Datafile 2).

We found a highly significant enrichment, treated as a sample of either ordered or disordered regions (P<1e-20).

Differential expression was also highly significant ( P < 10 −20 ) for previously described TB markers, such as IP-10, LBP, FCG3B, and TSP4, and for many novel proteins not previously associated with TB.

Statistical testing further confirmed a highly significant increase in DSC and decrease in AVG HD for both improvements (competition and information aggregation) compared to QuickNAT (Wilcoxon signed-rank test, p < 10 −20 after Bonferroni correction for multiple testing).

The overlap of Arc-dVenus -enriched genes with activity-regulated and visual stimulus-induced genes is highly significant (each p < 10 −20 , hypergeometric test) ( Fig. 3C,D ).

Moreover, the overlap between the hyper- and hypo-methylated ESSEs in the Jurkat cells and DLBCL samples was highly significant ( p-value < 1E-20) (top panels, Fig 8B ).

The overlaps between the studies were highly significant in most cell types ( P < 10 −20 , hypergeometric test) with the exception of the case of chimpanzee OPCs, because no genes were shared in this case ( SI Appendix , Fig.

The highly significant enrichment patterns ( p <1e −20 ) highlight three fundamental mechanisms underlying GR’s superior thermotolerance.

A highly significant association peak (–log 10 ( P ) = 19.89) was identified on chromosome 1, exceeding the significance threshold (interval: 36,313,286–36,586,879 bp, spanning approximately 273.6 kb).

The intraclass correlation coefficient (ICC) for the accuracy rate was 0.982, indicating near-perfect agreement between raters, with a highly significant F test ( P = 1.36 × 10 −20 ).

The relationship between the time point and membership of the clusters was highly significant (chi 2 P = 1.4 −20 ).

The association between PRS and phenotypes of the same trait were highly significant (PRS 25-OH-D p = 1.4e − 20, PRS n3-PUFA p = 9.3e − 6, PRS MDD p = 1.4e − 4).