“highly significant”

Results With all possible fMRI contrast parameters, the three-factor models were highly significant ( p < 1.0 x 10 -21 ).

Highly significant associations for a nonsynonymous SNP (rs12075; G42D ( NP_002027.2 ) ( p = 1.3E-21) and an intronic SNP ( p = 3.6E-13) in DARC on chromosome 1 were identified for MCP-1.

Rs17822931-G showed highly significant association in the combined samples of 174 cases and 201 controls (P = 1.42E-21, OR = 83.94, 95% CI = 83.03–84.85).

The difference between CTA and all genes was highly significant with Mann–Whitney U test p -value = 1.47E-21, and likewise for CTX versus all genes with p -value = 1.16E-23.

MR analysis in the same study provided further highly significant evidence of a causal relationship between mLOY and AF (HR: 1.15, 95% CI: 1.13–1.18, p = 1.52 × 10 −21 ).

2 B) but with a highly significant effect ( P = 1.57*10 -21 after PLS-DA cross-validation ANOVA). 3.3.

( 2017 ) overlapped with our set of 2,379, which is highly significant (hypergeometric test p = 16.8 × 10 –22 ) and suggestive of commonalities among transcriptomic stress responses, whatever the underlying trigger.

Two highly significant DMRs (DMR1 p = 2.72E-21; DMR2 p = 1.84E-08) were discovered within the primary and alternative promotors and leading exons of the MAP2K3 gene that encodes the MAP kinase kinase, MKK3 (Fig. 4 b).

This overrepresentation of prophage DNA is highly significant (binomial test, P = 3 × 10 −21 ).

The mean ΔPPD ( ± SE) for the bTB+ animal group was 1170.35 ± 84.48 compared to −360.46 ± 55.17 for the bTB− group and this group difference was highly significant (two-tailed Wilcoxon rank-sum test; P < 3.258 × 10 −21 ) (Supplementary Fig.

In fact, highly significant abundance of cis configurations of PFA-nsSNPs was obtained, with a global cis/trans ratio of 59.6:40.4 ( P < 3.53 × 10 −21 ) (Table 1 ).

Thus, more than 50% of TCF target genes were differentially expressed in the 2 subpopulations, reflecting highly significant enrichment for TCF1 target genes among differentially expressed genes ( P = 3.56e-21).

In monocytes, highly significant enrichment was observed for regulation of inflammatory response (GO:0050727, p = 3.95 × 10 −21 ), positive regulation of innate immune response (GO:0045089, p = 2.69 × 10 −18 ), the innate immune response-activating signaling pathway (GO:0002758, p = 2.69 × 10 −16 ), canonical NF-kappaB signal transduction (GO:0007249, p = 3.00 × 10 −9 ), and the tumor necrosis factor-mediated signaling pathway (GO:0033209, p = 0.001).

We observed a highly significant correlation between the signature count score and ME in the Test dataset (OR = 1.23 per standard deviation increase, p = 4 × 10 − 21 ) when including sex and the top 10 genetic principal components as confounders in the logistic regression.

This SNP was also highly significant in our analysis ( p = 5.4 × 10 −21 , beta = 0.27 years, effective-allele = G).

Finally, Fbp1 had a highly significant cis eQTL (rs13481847; P =6.1×10 −21 ) in the cochlea that maps ∼100 kb upstream of our peak GWAS SNP on chromosome 13 for ABR threshold after a 24-kHz tone burst.

Results demonstrated that all the three main effects were highly significant: semantic context, F (1,65) = 189.567, p = 6.12e−21, partial η 2 = 0.745; F 0 contours, F (1,65) = 277.133, p = 3.948e−25, partial η 2 = 0.81; group, F (1,65) = 22.554, p = 1.167e−5, partial η 2 = 0.258.

This is a highly significant overlap ( p = 6.14 × 10 –21 by hypergeometric probability).

Urate is relatively low down the list (27 th position), but nonetheless enough data is available to yield a highly significant (top hit p-value = 7.29 x 10 -21 ) GWAS result ( Figure 1 ).

Discussion The BCO2 mutation ( c.196C>T ) identified in the present study showed a highly significant (P = 7. 44 × 10 -21 ) association with yellow adipose tissue in 428 genotyped sheep.

GO overrepresentation within the 531 gene cluster 7 (macronuclear G1/S, late micronuclear S) showed a highly significant enrichment for processes linked with S phase, including DNA replication ( P = 1.00E-20), DNA repair ( P = 1.03E-18), regulation of the G1/S transition ( P = 0.04), and histone modifiers ( P = 3.36E-3) ( Figure 6B ; Supplemental Datafile 2).

We observed highly significant ( p < 1e−20) enrichment for the GO biological process (BP) term “translation”, GO molecular function (MF) term “structural constituent of ribosome”, and GO cellular compartment (CC) term “ribosome” among GO terms for differentially downregulated genes in external cortical tissues after 3 months of storage.

Each of the three possible pairwise regressions were highly significant with p<10 −20 .

There is a substantial (average coefficient -0.6) highly significant (p<10 −20 ) shift of the distribution towards negative values for contrast-dependence (bottom histogram), together with a mild (∼0.16) less significant (p<0.01) shift towards positive values for SNR-dependence (top histogram).

We found a highly significant enrichment, treated as a sample of either ordered or disordered regions (P<1e-20).