“highly significant”

Consequently, there was a highly significant underrepresentation of such differentiation profiles such as the VERHAAK_GLIOBLASTOMA_PRONEURAL signature in the clones (nominal P = 0.000446; Fig. 4C ), along with an enrichment of mesenchymal gene sets such as HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION (nominal P = 0.000227; Fig. 4D ).

Half of the 44 individuals in group 2 exhibited SBS18 in their CRC, representing a highly significant increase over group 3 (2.7-fold odds ratio, P = 4.48 × 10 −4 ; Table 1 , Fig. 4 , Supplementary Tables 1 and 2 ).

A highly significant global association was detected in female participants (global P = 4.5×10 -4 ), whereas no evidence of a comparable association was observed in males.

After FDR adjustment, exon 6 showed a highly significant enrichment of mutations in BC ( p = 0.00045), whereas no significant difference between exons 5 and 6 was observed in OCC ( p = 1.000) or PC ( p = 0.384).

We also found that the inhibition of PAI-1 activity with a small molecule PAI-1 inhibitor TM5275 almost completely restored the p53 protein degradation rate that was inhibited by bleomycin in A549 cells (the time-dependent changes in the amounts of p53 protein between bleomycin + TM5275 and bleomycin + solvent were highly significant, p = 0.00046; those between bleomycin + TM5275 and saline + TM5275 were not significant, p = 0.626; those between bleomycin +TM5275 and saline + solvent were not significant, p = 0.945) ( Figure 3 D,E).

In fact, when patients treated in first and second line of therapy were taken together this association was highly significant (p=4.6 x 10 –4 , n=64).

4 × 10 −4 ) and highly significant (median predictor cross-validation P = 4.6 × 10 −4 ), consistent with previous findings that low average heritability of gene expression can be compensated for by sample size sufficient to produce reliable genetic predictors ( Supplementary Table 7 ).

This confirmed a highly significant association between day 21 large clone count and six-month outcome, with responders having on average 5.7 more large clones on day 21 (95% CI: 2.6 - 8.87, P=4.8×10 -4 , Supplementary Figure 1 ).

As shown in Figure 4A , 10 min of retinoschisin treatment slightly reduced Src phosphorylation (86.8 ± 2.9%) compared with control treatment but with a statistically highly significant difference between retinoschisin and control treatment ( p = 4.9 × 10 -4 ).

A quantitative analysis demonstrated that TGF-β1 elicits tube formation in fibrin gels in a dose- and time-dependent manner, a highly significant (p < 0.0005) effect being observed after 48 hours of treatment with TGF-β1 concentrations as low as 20 pg/ml (Fig. 3E ).

Comparison The movements on the surgical side were larger than those on the orthodontics only side, but this difference was significant only during the second half ( p < 0.05) and highly significant ( p < 0.0005) only when considering the overall tooth movement.

In contrast, the correlation between genetic and geographic distances remained highly significant after controlling for temporal variation (r=0.55, Zr=0.55, p<0.0005).

However, a highly significant decrease of the transcript levels of the DA degradation enzyme COMT was observed in both A53T-SNCA overexpressing mouse lines ( Fig. 3 ; PrPmtA: −30%, n = 6, p = 0.0005 and PrPmtB: −26%, n = 7, p = 0.0018).

This relationship was fit using gamma regression and a log link, the results of which were highly significant (p < 0.0005, Supplementary Fig.

There was a highly significant treatment by time interaction effect (likelihood ratio test, chi-square = 15.155, df = 2, P = 0.0005), which was largely located after day 21 as indicated by the tests of the interaction parameters in Table 3 .

A chi square test with Monte Carlo simulation for the counting data resulted in a highly significant association between species and cultures with P = 0.0005, revealing that the ensemble was equivalent to more than one biocultural unit.

HIV-1 infection was a highly significant risk factor for adults with severe malaria compared with controls with uncomplicated malaria (odds ratio [OR] 12.6, 95% confidence interval [CI] 2.0–78.8, p = 0.0005) and asymptomatic controls (OR 16.6, 95% CI 2.5–111.5, p = 0.0005).

However, age demonstrated highly significant effects in both no-mask and surgical-mask conditions ( p < 0.0005), with older children performing better than younger children.

The AEC 220/μL cutoff classified the patients into two populations with highly significant different distributions ( p = 0.0005, Figure 1E ).

Comparison between rapamycin and HI treatment revealed opposed effects with highly significant difference ( p = 0.0005; Figure 5A ).

= 1 P = 0.02). Again there is no evidence of an interaction with batch (P = 0.19). Study 2 Table II and Figures 3 and 4 show the results of the second study which examined the dose response relationship of 4-OHA. There is a highly significant difference between control rats and those treated with 4-OHA, both in terms of tumour free survival (Logrank test for trend = 29.49 d.f. = 1 P <0.0005,) and overall survival (Logrank test for trend = 23.22 d.f. = I P <0.0005), confirming the results of the first study.

The differences between the three subgroups were indeed more pronounced when considering only children over the age of one year: subgroup α contained 89% of the UM and 79% of the SNCM patients but only 11% of the CM patients, whereas 78% of CM patients were found in subgroup β ( figure 4b ), and the association with clinical status was highly significant for both (p = 0.0005 and 0.0004, respectively).

Serum testosterone and estradiol 17β levels were lower in those with RAD, but only the difference in testosterone was highly significant (1.0 ± 0.7 vs 2.7 ± 1.2 ng/ml, P = 0.0005) (see Supplementary Table 1 ).

These titers exceed by >1 log the highest titers detected by earlier assay methods (29-31), and the difference between the seropositive patients and normal controls was highly significant (p < 0.0005).

These differences were determined to be highly significant (P < 0.0005).