“highly significant”

The correlation between the clock time estimate and clock time setting deviations was highly significant ( r =−0.88, p < 0.0002).

Between visit spectral changes were highly significant ( p = 0.0002) and were related to protein structure.

For confirmation, we applied IFNA16 rs28368163 as a tag SNV in a second ET validation cohort (n = 54) and reconfirmed a highly significant association ( P = .0002) and OR (4.51; CI, 1.92-10.56), nearly identical to that found in Cohort 1 ( Table 2 ).

Number of ChAT- and TrkA-ir Neurons in L1 Tau Mice Differ from the Wild-Type Controls For interneurons in NAc, a factorial two-way ANOVA with the genotype and treatment for the core groups confirmed the highly significant main effect of the genotype (F(1,31) = 18.2; p = 0.0002).

Applying the GEPHAST analysis separately to each of the three groups defined by STRUCTURE (assuming each group to be homogeneous) reveals a striking pattern in which both INRA111 and BMS2753 yield highly significant associations in just one of the three groups (P = 0.0002 and P = 0.0005 respectively, corrected for 30 tests).

However, during reversal phase, the analysis of trials to criterion revealed a highly significant effect of WD in both 7 and 16 months old mice (Two-way ANOVA p = 0.0002, Bonferroni post tests * p < 0.05; Figure 1D ).

A highly significant negative correlation emerged when combined hormone receptor status (ER+ and/or PgR+) was considered ( r = −0.36, P < .0002, Table 3 ).

Logistic regression revealed that the individuals with the homozygous mutant genotype ( GG ) show a substantial 2-fold increased likelihood of developing COPD, a highly significant result ( p = 0.0002, FDR = 0.002).

Although observing two siRNA sharing a hexamer seed sequence is not significant at the 5% level, observing two or more such seeds is significant (P = 0.013), while finding four siRNAs sharing a seed sequence is highly significant (P < 0.0002).

A highly significant difference in distribution of deaths by suicide (χ 2 = 36.20, df = 11, p = 0.0002) was shown, which were found in both genders (Male: χ 2 = 21.00, df = 11, p = 0.0335; Female: χ 2 = 47.74, df = 11, p = 0.00002).

Comparing the mRNA levels of tissue samples obtained from the dorsal horn of control animals and from the dorsal horn of CFA-injected animals ipsilateral to the CFA injection at post-injection day 3 (at the peak of mechanical allodynia), we observed a highly significant, approximately six times increase in the IL-1R1 mRNA ( p = 0.0002) in the experimental animals (Table 2 ).

Contribution to the Next Years’ Spring Peak We investigated the correlation between the abundance of the spring generation (dependent variable) and the abundance of either of the two generations the year before (independent variables) with a multiple linear regression model: the contribution of the second generation to the abundance in spring next year is highly significant ( R 2 = 0.80, P < 0.0002), while the contribution of the first generation is not significant ( R 2 = 0.17, P = 0.21) ( Figure A8 a).

Comparison of relative T m of soluble HLA monomers with normalized anti-HLA MFI values generated by the cell-based assay revealed a striking and highly significant correlation at peptide concentrations of 100 μM (R = 0.87, p = 0.0002) and 10 μM (R = 0.85, p = 0.0004) ( Figures 3 D and 3E).

At the same time, 4 patients encountered graft-rejection, and 7 patients died of HSCT-related complications, indicating a highly significant impact of HSCT on the survival rate of patients with actinopathies ( p = 0.0002, Figure 3 ).

With covariate adjustment quiescent ulcerative colitis patients demonstrated a highly significant 55% lower number of colonic tuft cells as compared to controls (95% CI, 31–71%, P = 0.0002).

Moreover, rectal mDCs after the 1st Ad-SIV immunization exhibited highly significant positive correlations with rectal IFN-γ + CD8 + memory T cells specific for SIV Gag ( r = 0.7356, p = 0.0002), SIV M766 Env ( r = 0.5979, p = 0.0054), and SIV CG7V Env ( r = 0.7615, p < 0.0001).

This decrease was highly significant compared with the control group ( p < 0.0002) and reflected a decrease in sulfate incorporation of 48% (Figure 1a ).

Interestingly, our data revealed that a highly significant increase in myocilin expression (11.8-fold) was observed in TM region of the responder eyes compared to vehicle-treated eyes ( p = 0.0002); and there was a fourfold increase in myocilin expression in GC responder eyes ( p = 0.0004) compared with GC non-responder eyes.

To reduce the bias of time to HSCT2 we analyzed only patients having HSCT2 within 6 months of relapse and found that having HSCT2 was a highly significant predictive factor in this univariate analysis ( P =0.0002).

The results as shown in Figure 5B , demonstrated a highly significant correlation for RIα up-regulated genes ((p < 2E-4) and RIIβ down-regulated genes (p < 1E-11) and the gene expression differences which distinguish myoblasts from myotube cells.

Comparison of the combined values with T112i3 mAb to the values without T112/3 mAb showed that the effect of CD2 activation on mo- tility was highly significant, p = 0.0002.

In addition, a weak yet highly significant positive correlation (rho = 0.49, p -value = 0.0002) was found between the overall metabolite load and the cell size during the growth phase ( Figure 5B ).

At the lower dose of sucrose and higher dose of OLE, a highly significant decrease ( p < 0.0002) in peak glucose was observed in all individuals (Fig. 8 ).

A highly significant negative correlation was seen between Mig-6 and FPG (r=−0.4991, p=0.0002), HbA1C (r=−0.4649, p=0.0008), and HOMA-IR (r=−0.4272, p=0.0027) ( figure 3 A).

A highly significant interaction emerged with factors WordType, PeriExtra, TempFront and Areas ( F 2, 22 = 14.012, p < 0.0002), revealing different CA circuits across the 12 area network between object- and action-related words.