“highly significant”

In 12,899 patients, the improvement in the ROC curve area of APACHE III compared with APACHE II was highly significant (P < 0.0001).

The interaction between current density and treatment time plays a decisive role in coating development, with a highly significant effect on hardness (IT = − 18.25, p < 0.0001).

Similarly, there was highly significant variation among the 31 samples (F = 19.0; p<0.0001), with individual mean values ranging from a low of 52.6 (SF 009) to a high of 88.3 (EC 101).

The interaction term for eGFR and urine ACR was highly significant ( P <0.0001, multiplicative interaction term), indicating that eGFR significantly modified the association between urine ACR and incident AF (Table 2 ).

Furthermore, these individuals have highly significant improvements in Clarke and HYPO scores ( P > 0.0001)—hypoglycemia awareness.

Because of the large number of residues examined, the differences in the means between conserved and non-conserved structures are highly significant (p < 0.0001).

Of these, eight showed highly significant hypermethylation in tumor tissue (p < 0.0001): GDNF, MTHFR, OPCML, TNFRSF25, TCF21, PAX8, PTPRN2 and PITX2.

The Wilcoxon signed-rank test yielded a highly significant result ( P < 0.0001), demonstrating a significant difference in histological scores between the jejunum and ileum, suggesting a potential systematic variation in lesion scoring across different intestinal segments.

There was a highly significant correlation, r = −0.54, p < 0.0001, between the α and τ parameters, such that the higher the modeled α , the smaller the modeled τ .

For both traits, we detected highly significant differences between genotypes (subplots, P< 0.0001), with the 1RS xR lines showing higher NDVI and grain yield than the 1RS xW lines ( Fig. 1 ).

The point of parturition (P) itself marks a highly significant decrease in albumin levels in RFM cows compared to NP cows ( p < 0.0001), reflecting a major physiological impact during this critical time.

When the results of all segments were combined, the difference in viral mutation rates by host group was highly significant (ANOVA, P < 0.0001; Table 2 ).

At 35 days after MCAO, a highly significant tissue loss of the IL neocortex and striatum was present in both MCAO groups (P < 0.0001; Figure 4(c) ), however to a lesser extent for the CCA-MCAO group.

During intervention with the oil-free hydroethanolic pumpkin seed extract, there was a highly significant reduction of symptoms after 12 weeks of supplementation (baseline: 15.7 [95% CI: 14.5–16.8]; after 12 weeks: 10.8 [95% CI: 9.5–12.0]; P < .0001).

Cells infected at 0.1 and 1 MOI were highly significant in viral mRNA levels compared to cells infected at MOI 10 ( p < 0.0001 for both, but MOI 0.1 and MOI 1 were not significant from each other), while the viral mRNA levels from the cells infected with ISAV at MOI 10 did not differ significantly from uninfected cells ( p = 0.9).

The type of test used was highly significant (p<0.0001) for milk production, probably because the data used in the meta-analysis included one-day tests as well as 305-day tests.

Substance P cells showed a higher frequency of both sEPSCs and mEPSCs (6.04 ± 0.96 Hz sEPSCs, 3.24 ± 0.67 Hz mEPSCs, n = 27 and 11, respectively) than GRP cells (0.2 ± 0.05 Hz sEPSCs, 0.02 ± 0.01 Hz mEPSCs, n = 120 and 32, respectively), and these differences were both highly significant (sEPSC, Mann–Whitney, U = 68, P < 0.0001; mEPSC, Mann–Whitney, U = 0, P < 0.0001; Fig. 6 ).

Among treatments, QE and QL produced the highest reduction in bait intake, particularly at higher concentrations (50 and 100 ppm), where differences were highly significant ( p < 0.0001) for both sexes.

Results Applying a vote‐count strategy to search for the intersection of genes reported in multiple independent studies with a consistent fold‐change direction, followed by a Monte Carlo simulation, we identified 528 highly significant differentially expressed multi‐study genes ( p < 0.0001; 10,000 simulations).

The p-value indicates highly significant **** p < 0.0001 while p > 0.05 is considered not significant.

These changes were associated with a highly significant main effect of genotype ( F (1, 10) = 100.5, p < 0.0001).

The median (IQR) growth rate of children pre- and post-tests were −4.0 (−5.4–−2.1) SDS and 0.1 (−1.9–1.4) SDS respectively, a difference highly significant ( p < 0.0001) (Fig. 3B ).

Overall, there was a highly significant skew toward sub-telomeric location for CNV genes compared with non-CNV genes ( p < 0.0001, Kolmogorov-Smirnov test; Figure 1B , Table 1 ).

All smooth functions were highly significant ( P < 0.0001).

Thus, during the transition from pole to brain control in task 1, the average correlated firing between pairs of cortical neurons, measured in terms of correlation coefficient (mean ± SEM), increased from 0.02 ± 1 × 10 −4 to 0.06 ± 2 × 10 −4 , a 3-fold rise that was highly significant (Wilcoxon signed rank test, p < 0.0001).