“highly significant”

In U87 cells, upon RT, GSI and TMZ did not affect the clonogenic survival compared with the vehicle control (DMSO), however the survival fraction was markedly reduced in the GSI + TMZ treatment group at 2,4, and 6 Gy and a highly significant synergistic effect was observed ( p < 0.0001) (Figure 2C ).

Further assessment of the line x environment interaction using rank correlation analyses between pairs of environments found highly significant ( p < 0.0001) correlations for the Striga resistance-related traits (Supplementary Table S1 ).

total and stage I+II ovarian cancer is highly significant (P<0.0001) but negligible for healthy vs. stages III+IV cancer (P = 0.043); in contrast for the more important differentiation between benign vs. ovarian cancer, the difference between CA125 and the panel is missing for benign vs. total and stage I+II ovarian cancer and rather better for benign vs. stage III+IV ovarian cancer (P = 0.045).

The mean time to perform SAB was shorter in group-A with value 3.03 ± 0.72 min which is statistically highly significant having P value < 0.0001 when compared to group-B with value 7.73 ± 1.44 min.

In contrast, a highly significant negative correlation was detected between the frequency of mucosal CD3 − CD20 − TGF-β + cells and CD4 + T cells in SIV infected animals ( r = −0.582, p < 0.0001, Figure 3 E). 3.4.

The mean wheal size of S-DP was significantly higher than C-DP across all dilutions, which was highly significant with P value of <.0001 ( Table 2 , Figure 3 ).

The correlation matrix shows a highly significant relationship ( r = 0.38–0.43, P < 0.0001) between all three scores (Table 4 ) indicating internal validity in scores assigned for each measure.

For example, Fig 5 shows one example of a highly significant relationship between the date and phi (β = 1.779, p<0.0001).

Species type had a highly significant effect on AK release ( p < 0.0001), but adding AmB did not ( p = 0.14), and there was no significant interaction between these factors ( p = 0.069). Šidák’s post hoc analysis confirmed that C. albicans released significantly more AK than C. glabrata in response to both LIPUS alone ( p = 0.02) and LIPUS combined with 1⁄4 MIC AmB ( p = 0.0003).

In a retrospective multicenter study, the correlation between SWV values and histological fibrosis was highly significant ( p < 0.0001), even if a large overlap of values occurred in the stages of 2 or below, with only F ≥ 2 and cirrhosis being excluded with great certainty [ 39 ].

For both assessors, this difference in the immune cell pattern was highly significant (p < 0.0001).

Consistent with this, analysis of data obtained from the Cancer Cell Line Encyclopedia [ 28 ] ( http://www.broadinstitute.org/ccle/home ) of 47 colon cancer cell lines for mRNA expression reported as a robust multi-array average (RMA) of CDCP1 and CD9 showed a highly significant positive correlation (p = 0.0001) between CDCP1 and CD9 mRNA expression by Pearson correlation analysis (Figure 2 D).

Results Kaplan­Meier analysis showed a highly significant difference in OS between the CMR and N-CMR groups (log-rank test p < 0.0001).

IE2 positive cells showed a highly significant ( p < 0.0001) down-regulation of CD83 surface expression ( Figure 5A , white bar) which could be prevented by the addition of the proteasome inhibitor MG-132 ( Figure 5A , gray bar).

Abnormal renal function tests (higher levels of serum urea and creatinine) were reported in our study and the difference was found to be highly significant (urea (p<0.0001) and creatinine (p=0.0019)) between the controls and cases.

The mean satisfaction scores between PRP therapy and minoxidil therapy were highly significant ( P = 0.0001).

The use of tramadol for analgesia was confirmed as a highly significant contributing factor for NAE (OR, 6.3; 95% CI, 3.0 to 13.4; P < 0.0001).

Correlation between Serum Mg Concentration and Isotopic Composition There is a lack of significant correlation between the serum Mg concentration and isotopic composition in all but one dataset between the present study and Grigoryan et al.—the exception being the T1DM group from Grigoryan et al., in which a highly significant inverse correlation was observed ( r = −0.70, p < 0.0001) ( Figure 4 ) [ 25 ].

Similarly, in the present study, as shown in Table 3 , there is statistically a highly significant correlation ( P <0.0001) between mean PPD and the AST levels in GCF at baseline (0-month) suggesting that during the diseased state, as the mean PPD increases, the mean AST levels in GCF also increase.

The model F-values were found to be highly significant for both responses (vesicle size and entrapment efficiency), with p-values < 0.0001 for vesicle size and 0.0014 for entrapment efficiency.

First, the 3 × 3 TSM table for a candidate C‐PAS must show a highly significant targeting preference ( P < 0.0001, 8 df).

The analysis of variance confirms that the model is highly significant as is evident from Fisher’s F -test (104.99) and a very low P -value < 0.0001.

41 Both endpoints demonstrated profoundly better results in the colchicine group than in the placebo group that were highly significant, and acetaminophen consumption was substantially lower in the colchicine group (P < .0001 for all outcomes). 41 Leung et al. took a similar approach in 2018. 42 Patients meeting the ACR criteria for symptomatic and radiographic knee OA, along with a positive response to the frequent knee pain quest

Study Sites We found highly significant differences among the three study zones for impervious surface ( F 2 , 36 = 52.0, p < 0.0001) and relative heat ( F 2 , 36 = 32.5, p < 0.0001), and in the predicted direction.

25 Furthermore, during milk OIT, the risk of reactions and the need for epinephrine treatment was highly significant ( p < 0.0001). 25 These patients were also at a higher risk of OIT discontinuation or not achieving full desensitization.