“highly significant”

To formally test this, we compared H3 BioID interactors with the MYC interactome ( 56 ), finding a highly significant overlap ( p = 10 −134 ; Fig. 3 G ).

The yield difference between the two basins was highly significant (t = 46.11, p < 10− 133 , Cohen’s d = -2.77), confirming the stark separation of performance states.

Also, notable in cluster 0 res0.75 was a highly significant enrichment (p=6.8×10 -133 ) of genes associated with the NGF-TrkA growth factor tyrosine kinase signaling pathway [ 31 ].

Similar to the genome-wide comparison, we found a highly significant non-parametric correlation coefficient (Spearman's r = 0.62, P = 1.2e-132) for the expression change of these shared differentially expressed genes ( Fig 5A ).

In fact, the correlation between hearing and deaf regional thickness measurements was highly significant (p = 6.85 × 10 −132 ), demonstrating an R 2 value of 0.98.

Five genes associated with pigmentary traits were identified in the analysis with highly significant SNP associations: SLC45A2 (rs16891982, β=−0.546, SE=0.021, p=2.2×10 −130 ), IRF4 (rs12203592, β=1.915, SE=0.118, p=2.8×10 −57 ), HERC2 (rs1667394, β=−0.608, SE=0.02, p=2.8×10 −176 ), OCA2 (rs11855019, β=−0.548, SE=0.022, p=2.4×10 −121 ) and MC1R (rs1805007, β=3.615, SE=0.326, p=7.7×10 −22 ) (online supplementary figure S3 ).

Especially, VIT_00s0324g00050 showed highly significant differential expression ( P = 3.79E-129). qRT-PCR analysis To confirm the results obtained from RNA-seq, relative expression profiles of 30 genes were analyzed by real-time RT-PCR at the three fruit developmental stages in black and white spine grapes.

For KEGG GSs, there was a large number of highly significant GS associations (minimum nominal p = 3.84x10 −129 ); however, the majority of the top results were driven by the 13 GSs which include the human leukocyte antigen (HLA) genes.

Here, only the Cosine and Jaccard results are highly significant ( P < 1.05*e −128 ) when comparing the merged and the study-wise annotation model.

Changes to plan shape Throughout the entire handaxe sample, the correlation between tip length and PC1 ( Fig 14 ) is highly significant (r = .642, p = 1.2889E-128), supporting an allometric relationship between handaxe shape and size.

In our sample, the correlation between FA and MD values was highly significant (whole-brain average r (FA,MD) =−0.75, P =9.9e–128).

The correlation between total viral genome copies and sub-genomic E gene copies was highly significant ( p = 3.81 × 10 −127 ), but a high level of variance was observed between live viral titres measured by focus forming assay and both total and sub-genomic RNA titres ( Figure 4 a).

Here, the intersection of p63-binding sites and KMT2D-depleted genes was highly significant ( P = 9.75 × 10 −127 ) ( Fig. 3 F; Supplemental Table S3C ).

We also observed a highly significant increase of Prl expression (adjusted P -value = 9.11 × 10 −126 ) in the somatotropes of lactating mice compared with the control (Fig. 5 C).

Compared to size-matched random genomic regions, K122Q-bound enhancers showed highly significant enrichment of the canonical CRE motif (Fold Enrichment=13.7, P =1.0 × 10 -125 ), with 42.5% of enhancers containing the motif versus 3.1% of background regions ( Supplementary Fig. 2 ).

We found a highly significant association (P = 1.0×10 −124 ) of the risk allele at the LIPA locus with LIPA mRNA levels in these cells explaining ∼50% of the variance in the expression of the gene ( Figure 6 ).There were no other highly significant associations between CAD risk alleles and gene expression at the novel loci ( Table S7a and S7b ).

On the contrary, the associations of the rs2519093 with concentrations of sE-selectin and sVCAM-1 were highly significant when adjusted for the ABO blood type (p=3.40×10 −123 and p=3.43×10 −17 , respectively).

[ 19 ], 244 were significantly positively correlated to YAP1 expression in the GSE45547 expression dataset, demonstrating a highly significant enrichment ( Figure 6 B; Hypergeometric test, p = 1.961398 × 10 −122 ).

Though no single pPGS reached the same degree of significance as the gwPGS, interactions were highly significant for multiple pathways, including glycerolipid metabolism ( p = 2.0 × 10 −122 ) and focal adhesion ( p = 2.9 × 10 −60 ) ( Figure 2 A).

We observed a lesser, but still highly significant, overlap between H3K27me3 marked loci and gene body methylation in CIMP-L1 (13.1%; P = 6.11 × 10 -122 ) and CIMP-L2 (8.5%; P = 1.6 × 10 -78 ) cancers, but did not observe any correlation in CIMP-neg cancers, which likely is owing to the scarcity of which gene body methylation occurs in these cancers.

This enrichment was highly significant ( P = 2.35 × 10 −121 ) with an odds ratio of 12.90, indicating that outlier SVs were nearly 13 times more likely to occur within regions of elevated genetic differentiation based on SNPs.

Comparison of Scrib module and PcG mutant RNA-Seq datasets revealed that nearly half of the genes upregulated upon polarity loss are also upregulated in PcG mutant tissues, a highly significant enrichment (p < 6.98e-121, Figure 6C ).

SUPPA2 identified 2576 events from 1482 genes, with a highly significant overlap in differentially spliced genes between the two approaches ( P = 10 −120 ; Supplementary Fig.

Hypergeometric tests revealed that the number of mutations in coding sequence compared with noncoding sequence was higher than expected by chance, suggesting a highly significant enrichment of mutations in protein-coding genes ( P = 3e-120).

1c and 1d ) is highly significant ( χ 2 test-statistic = 548.68; d.f. = 2; N = 1,913; P = 7.2 × 10 −120 ).