“highly significant”

In both cases, we found it to be highly significant (R = 0.92, p -value = 4.15 −151 for DNA and R = 0.98, p -value <8.7*10 −286 for RNA, Fig. 1d,e , respectively, Supplementary Data 2 ).

Interestingly, this trend is highly significant ( P < 10 -150 ) for all event lengths except for 3 bp, showing that degenerate codon positions evolved to reduce the indel propensity of frame shifting indels more than frame conserving mutations.

In particular, 22 and 17 elements were detected for microRNAs 128 and 138 MREs, respectively, with a highly significant enrichment ( P < 1E −150 , Supplementary Figure 3 and Supplementary Table 3 ).

H3K27ac/mC (Fisher’s two-tailed P = 6.5598e-292), H3K4me3/mC (Fisher’s two-tailed P = 3.0205e-273), and H3K4me3/H3K27ac (Fisher’s two-tailed P = 0) were commonly found pairs that were highly significant ( Figure 1B ), and the most frequent triplet marks were H3K4me3/H3K27ac/mC (Fisher’s two-tailed P = 4.8021e-150) and H3K4me1/H3K27ac/mC (Fisher’s two-tailed P = 7.8464e-17).

For five quantitative traits (BMI, DBP, FEV, RHR, and SBP), per-standard deviation (perSD) Beta values for rvPRS showed highly significant associations (max P = 1.21E-149; significance threshold P < 1.26E-04 = 0.05/18/22).

Although the overall results were highly significant for all methods, P values from the tests were the most significant for ReMM ( P = 1.5 × 10 −149 ), FATHMM noncoding ( P = 2.9 × 10 −121 ) and Eigen ( P = 2.5 × 10 −114 ), while P values for fitCons ( P = 6.0 × 10 −11 ) and GWAVA unmatched ( P = 7.3 × 10 −13 ) were the least significant, consistent with the AUC results.

\usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\bar{w}\left({n}_{{wt}}\right)=$$\end{document} w ̄ n w t = 0.48, a difference that is highly significant ( P = 3.8 × 10 −148 , two-sided Mann–Whitney U = 43,750, n = 681).

They discovered and validated a strong signal (p = 1.1 × 10 −10 ), at KCNJ2 , a locus that was also highly significant in our results (p = 4.2 × 10 −148 ).

The precision of this alignment was further quantified, showing a 74.5% overlap between high-risk and tumor cell categories, with McNemar’s test 84 demonstrating a highly significant association ( P = 3.54 × 10 −146 ) (Fig. 5 d), thereby supporting SIDISH’s accuracy in identifying cellular drivers of poor prognosis within their spatial context.

This overlap was determined to be highly significant ( p = 4.6 × 10 −146 , Fisher’s exact test) with an odds ratio of 43.0.

Furthermore, Wilcoxon signed‐rank tests comparing the absolute prediction errors of RINAMI and the baseline model showed highly significant performance differences across the three Mega‐scale test subdatasets, with p ‐values below 0.01 in all splits ( p = 5.95 × 10 −145 , p < 1.00 × 10 −300 , and p = 1.39 × 10 −25 ).

Using MSigDB to perform gene set enrichment analysis 26 , 27 , we found a highly significant enrichment for binding sites in the Sp1/Krüppel-like factor family 28 ( p < 10 −144 by Bonferroni-corrected hypergeometric test) and for genes downregulated in Klf1 −/− cells ( p < 10 −57 ).

Although the sublamination of the IPL was clearly less organized than in the WT, in this very thin IPL-like neuropil the typical apical/basal pattern was still obvious ( Figures 2 G and 2I) and highly significant (p = 3.0 × 10 −144 ; Figure 2 J).

Another highly significant feature ( p = 5.1 × 10 −144 ) was the number of upstream AUGs.

The overlap between the EPRS and ESR1 LINCS signatures is highly significant (corrected FET p = 3.6e-143, OR = 8.86) (Figure 6B ).

5 G) included 773 genes, which is highly significant ( p = 8.5 × 10− 142 ) with a strong odds ratio of 10.27, indicating that the overlap is about 10 times more frequent than would occur by chance.

In particular, the fluorescence intensity of SUVs preferred by 15GALA-NP increased approximately 2 orders of magnitude compared to free GALA, showing highly significant skewness ( p = 1.12 –141) by comparing the two distributions in a two-sided Welch’s t -test.

The APOE genetic signal remained highly significant in an age-stratified GWAS, on participants with age 60 years or more (OR 1.7, 95% CI 1.63–1.77; P = 2.7 × 10 −141 ; Extended Data Fig. 6 and Supplementary Table 2 ).

Of these, 140 SNPs indexed differences in HDL- and LDL-cholesterol, triglycerides, C-reactive protein, fibrinogen, factor VII, apolipoproteins AI and B, lipoprotein-associated phospholipase A2, homocysteine or folate, some with large effect sizes and highly significant P -values (e.g. 2.15 standard deviations at P = 9.2 × 10 −140 for F7 rs6046 and FVII levels).

The Steiger analysis demonstrated highly significant directional associations for CEP68 using both blood ( p = 1.92 × 10 −137 ) and LAA ( p = 4.88 × 10 −49 ) eQTLs.

This overlap is highly significant by factor of over-representation (4) and P -value ( P < 3.1 e-136).

Genetic analyses uncovered a missense change, c.1288G>A; p.A430T, in the autophagy-related ATG4D gene on canine chromosome 20 with a highly significant disease association (p = 3.8 x 10 -136 ) in a cohort of more than 2300 Lagotto Romagnolo dogs.

Comparison of F ST values on chromosome 1 between PK10 and Thailand were highly significant (pairwise- t = 26.9, d.f. = 1934, p -value = 1.15 × 10 −135 ), and PK10 F ST values were greater than Thailand F ST values in 1387 of the 1935 genes compared (71.6%).

Figure 7B shows there was a highly significant overlap between the genes affected by cordycepin in the two cell lines ( P < 1.44 × 10 −135 by one‐tailed Fisher's exact test).

Furthermore, the Z-score-based meta-analysis of 1,239 animals in the exploratory cohort revealed a highly significant negative correlation between pH and lactate levels at the individual animal level ( r =–0.62, P =7.54 × 10 –135 ; Figure 1B ).