Barely Significant
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“highly significant”

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p=0.09

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highly significantP < 0.00010.0× alphaqualifiedgold
Otherwise, our shuffled genes would not show the highly significant statistical association in amino-acid divergence K a we observe between sequence domain pairs (Figure 5 ; Pearson's r 0.47, Spearman's s 0.45, P < 0.0001 for both).
The rarity of gene shuffling in conserved genes.
Genome Biol · 2005 · PMC1175970
highly significantp < 0.00010.0× alphaqualifiedgold
Mean performances and analysis variance The pooled ANOVA indicated highly significant differences for restorer lines, with a significant effect of environments and G × E interaction (GEI) ( p < 0.0001) for all of the studied traits, indicating substantial phenotypic variation among the 240 rice restorer lines across the three test environments for all of the traits studied.
highly significantp < 0.00010.0× alphaqualifiedgold
When the association was analyzed using 500 kb genome windows, a highly significant and positive, but very weak, correlation was found; gene density explained only 3% of the variance in off-target site density ( Figure 2C ; r = 0.17, p < 0.0001). 3.2 Targeted sequencing depth To estimate the coverage depth obtained by the bait-capture targeted sequencing approach at off-target sites, we computed the depth of coverage at pre-filtered variant sites identified by Mutect2 ( Figure 3A ).
highly significantP < 0.00010.0× alphaqualifiedgold
However, the strength of the association between water source (private well or regulated water utility) and blood Pb concentration is highly significant ( Z = 8.13, P < 0.0001) even when controlling for other variables that may indicate other exposure sources (such as household age, an indicator of the risk of exposure from dust and soil containing remnants of Pb paint).
highly significantp < 0.00010.0× alphaqualifiedgold
For a-wave amplitude, a two-way repeated-measures ANOVA with treatment and intensity as factors found that both were highly significant ( p < 0.0001 for both), and Bonferroni post hoc tests indicated significant pairwise differences in the three highest intensities tested (−1 to 1 log cd s/m 2 ).
highly significantp < 0.00010.0× alphaqualifiedgold
The antibody levels progressively increased with a subsequent booster dose, and all three immunized groups showed a highly significant ( p < 0.0001) elevation in OD values compared to the unvaccinated mice at 35 dpv (OD values: 1.38 ± 0.00, 1.23 ± 0.01, and 0.91 ± 0.01 for vToH-QMV, vToH-DMV, and wt, respectively) ( Figure 3 B, Table S3 ).
highly significantP < 0.00010.0× alphaqualifiedgold
The correlation of the DEC1-dependent signature was highly significant with the CD28-regulated gene list (P < 0.0001). 72% of the genes up-regulated by DEC1 were also up-regulated by CD28 co-stimulation, whereas 83% of the DEC1 down-regulated genes were again down-regulated by CD28 signaling ( Fig. 7, C and D , top).