“highly significant”

An excellent correlation was found among the four retina specialists for determination of each patient’s LINCL ophthalmic severity score, where all correlations were highly significant (all Kendall’s tau > 0.87, p<0.0001).

Multilocus epigenetic heterogeneity between sites was highly significant (Φ ST from AMOVA = 0.286, P <0.0001), with about 28% of total epigenetic variance in the sample being accounted for by between-site differences.

However, over time, the exercise speed of bves KO zebrafish significantly decreased, showing a highly significant difference compared to WT zebrafish ( Figure 3 D, p < 0.0001).

Establishment of Regression Equation Model and Significance Test Response-surface analysis ( Tables S2 and S3 ) yielded a highly significant model ( p < 0.0001) with non-significant lack of fit ( p = 0.1273), indicating that only random error contributed to residuals.

The difference between left cue and right cue conditions was highly significant (χ 2 = 16.1, p < 0.0001).

A highly significant difference was observed among age groups ( χ2 = 18.99 , P < 0.0001 ).

C comparisons (comparing 164 values) gave a low, but highly significant positive correlation (ρ = 0.37, P < 0.0001) between the data obtained by the Affymetrix and PCR arrays.

Results We observed a highly significant decrease in the presence of the KIR2DS2 and KIR2DS4 genes (OR = 0.15, 95% CI = 0.05-0.41, P = 0.0001; OR = 0.06, 95% CI = 0.02-0.2, P = 0.000, respectively) and in the presence of the KIR2DL5A gene (OR = 0.05, 95% CI = 0.02-0.14, P = 0.0000) in the TC group compared to the HC group.

Moreover, a highly significant positive correlation was found between miR-424 and each of miR-199a, miR-183, and miR-224 (rho = 0.555, 0.364, and 0.359, respectively, p < 0.0001), and between miR-215 with miR-217 (0.529, p < 0.0001), in addition to the correlation between miR-199a and miR224 (rho = 0.515, p < 0.0001), and between miR-183 and miR-215 (rho = 0.361, p < 0.0001).

By contrast, in NT animals, the success rate following the US stimulation of their visual cortex dropped to 38.1 ± 18.5% (s.d.), and the difference with the success rate following LS on the fourth day was highly significant ( p < 0.0001) (Fig. 6d and Extended Data Fig. 6 ).

Both models were highly significant ( p < 0.0001), with adjusted coefficients of determination (R 2 adj ) between 0.72 and 0.78.

A consistent decline in the number of AK lesions from day 3 to day 29 was observed for all three active treatments, and the difference between active treatments and vehicle was highly significant at day 57 ( p <0.0001) [ Table 1 ].[ 11 ] The severity of local skin reactions in the active treatment groups followed a dose-dependent pattern, peaked between days 3 and 8 then largely resolved by day 15.

Differences were considered significant at a probability level of P < 0.01 (*), very significant at P < 0.001 (**) and highly significant at P < 0.0001 (***).

In both conditions, there was a highly significant difference ( p < 0.0001) between experimental groups and control groups in learning per hour of instruction as measured by the test, confirming the intuitive judgment that one hour’s instruction replacing four months instruction demonstrates far greater efficiency in learning.

At 72 h, the inhibition was highly significant for the two differentiation induction media when compared with the control for each cell line (P<0.0001; Fig. 2C ).

A Mann Witney comparison showed that this difference was highly significant with p < 0.0001 adjusted for ties.

In the 325 mg cohort, plasma salicylate (1061–6299 ng/mL) and salicylurate (673–3355 ng/mL) were detected in 21/21 (100%) subjects ( Figure 4 B), gentisic acid (39–283 ng/mL) was detected in 20/21 (95%) subjects, and salicyl acyl glucuronide (31–396 ng/mL) was detected in 21/21 (100%) subjects ( Figure 4 C) following ASA exposure and were highly significant ( p < 0.0001 for each metabolite, paired t -tests).

Generally, temperature linear terms (X 3 ) were highly significant ( p < 0.0001) for most responses, except for FRAP and cyanidin-3-rutinoside responses.

However, there was a highly significant intra-subject correlation between pre- and post-treatment irisin concentrations (R = 0.82, P<0.0001).

As shown in Table S10 , the model had F = 10.65 and was highly significant ( p < 0.0001), while the lack of fit was not significant ( p = 0.0652 > 0.05).

As shown in Table 5 , there were negative correlations that were highly significant between HDAC4 levels and the BMI (r 2 =-0.66; P < 0.0001 ), PBF (r 2 =-0.58; P = 0.0012 ) and RANTES (r 2 =-0.8; P = 0.001 ) and a positive correlation with V O2 Max (r 2 =0.54; P = 0.024 ).

The correlation between the observed and expected gene expression ratios, performed by bivariate analysis using JMP 5.1 program, is statistically highly significant (Pearson correlation coefficient = 0.93 and p -value < 0.0001) ( Figure 3 ).

Considering all five species, the difference between the years is highly significant for O. kevoensis (χ 2 = 69.5, P < 0.0001), whereas in O. inclinans the difference is only marginally so (χ 2 = 4.6, P = 0.03).

4 D ) and the correlation after pooling across neurons was highly significant (Spearman correlation: ITD: r s = −0.92; ILD: r s = −0.89; both p < 0.0001; two-tailed t test; Fig. 4 E , F ).

Among the two hiPSC lines, the highly significant ( P < 0.0001, paired t test with Bonferroni correction) reductions in methylation observed for the donor L1 during hiPSC derivation (25.0% on average) far exceeded that seen for the lineage progenitor (12.5%) and L1-Ta subfamily (2.9%) ( Fig. 5C and 6B ).