“highly significant”

The log-rank (Mantel-Cox) test revealed highly significant differences between survival curves (χ2 = 86.49, df = 4, p < 0.0001), indicating that survival probability strongly depended on age at the time of infection.

Notably, significant suppression of proliferative activity was observed at 24 h (P < 0.05), with highly significant inhibition and negative proliferation observed at 72 h (P < 0.0001).

The pooled analysis demonstrated a highly significant overall RR of 4.51 (95% CI, 2.95-6.90, P < .0001) for adverse outcomes in the high-risk TGF-β1 group compared with the low-risk group.

After 120 days of therapy, pitting edema score increased significantly in racemic amlodipine group compared to (S)-amlodipine ( p = 0.038) and increment of score was highly significant ( p < 0.0001) with amlodipine compared with baseline value (Table 2 ).

The analysis of variance (ANOVA) revealed a highly significant model (F-value = 220.94, p -value < 0.0001), indicating that at least one of the studied factors (incubation time (X 1 ), initial pH level (X 2 ), AgNO 3 concentration (X 3 ), and temperature (X 4 ) significantly affected the rate of AgNPs biosynthesis.

As shown in Figure 5B , IGF1R mRNA expression showed a highly significant ( P < 0.0001) positive correlation with Nanog mRNA expression in CD34 + leukemia cells ( Figure 6B ).

The model exhibited good discriminatory power with a C-index of 0.731 and a highly significant likelihood ratio test ( p < 0.0001).

Both the paramagnetic media concentration and the applied current led to highly significant changes in the levitation heights of live and dead cells ( P < 0.0001) ( Fig. 4 C ).

This correction was highly significant, P < 0.0001 ( Table 1 ).

Throughout the biophysical simulations for ligand screening, the effects of each lipocalin, the ligand and their interactions on the dependent variable for the binding energy and distance from the active site were highly significant ( P-value < 0.0001; Table 1 ).

Overall differences across histopathologic categories were highly significant (Kruskal–Wallis p < 0.0001), and there was a strong monotonic increase in OCNI across the ordered categories from benign to malignant disease (Jonckheere–Terpstra p < 0.0001).

The impact of the respondents' perception of local professional norms regarding disclosure on their attitudes and behaviours was substantially highly significant (p<0.0001) and, importantly, it was independent of local culture.

Trend was highly significant for any HPV type, any high risk type, and low risk type, at p < 0.0001 for each, significant for HPV 16/18 at p = 0.0004 and HPV 16 at p = 0.0153, and not significant for HPV 18 at p = 0.2217.

Variation in Cardiac Mortality Risk by Age and Decade of Diagnosis For all cancers combined, a highly significant decreasing trend (2 P <0.0001) with increasing age at cancer diagnosis was shown for both SMRs and AERs for all cardiac disease (Table 3 ).

However, purge loss in cured pork sausages was highly significant with the addition of ligands ( p < 0.0001; Table 2 ), with cysteine treatment showing higher purge loss than histidine and nicotinamide treatments ( p < 0.05; Table 3 ).

All fitted models were highly significant ( p < 0.0001), with R 2 ranging from 0.72 to 0.99.

We observed a highly significant linear correlation between the cycle threshold (Ct) of both genes (beta-actin vs GAPDH, r = 0.912, F (1,46) = 157.73, p < 0.0001).

Statistical analysis confirmed that this reduction is highly significant ( p < 0.0001), indicating a pronounced structural distinction between both fiber populations.

Among the clusters of significant correlations that were identified, the most striking one was the highly significant positive correlation ( P < 0.0001; Spearman coefficient > 0.8) between all the platelet-activation markers, sCD62P and TLT1; and the platelet-derived products PDGFs, CCL5, PF4, and TGFβ1 ( Figure 5 , Supplementary Table S1 ).

Nonetheless, a highly significant and negative correlation between free-ABA and total anthocyanins was observed for both irrigation treatments ( r = −0.76, p ≤ 0.0001) in the 2 years.

Comparison between semiquantitative immunohistochemical evaluation and RT–PCR quantification of L1CAM transcripts resulted in a highly significant correlation (p < 0.0001; r s =0.663).

The Cd (ng/mL) levels in the blood of exposed workers were significantly higher than those in unexposed individuals, with mean values of 85.8 ± 0.83 versus 43.7 ± 3.07, respectively; differences were highly significant (p ≤ 0.0001).

Although these increases were highly significant (ANOVA: F 25,429 = 1434, p < 0.0001; F 13,95 = 13.64, p < 0.0001), they were really small (see Supporting Information Tables S4 and S5 ) in units of percent (females vs. males) both in WT and KO animals. 3.3.

A prespecified subgroup analysis (see Supplementary material online , Figure S6 ) demonstrated a highly significant interaction (χ 2 = 19.93; P < 0.0001), with a larger treatment effect in non-China studies (RR 1.30; 95% CI 1.23–1.38; I 2 = 0.0%) compared with China-based studies (RR 1.12; 95% CI 0.96–1.29; I 2 = 0.0%).

The effect of benzene was found to highly significant increased (P < 0.0001) in all biochemical parameters (AST, ALT, ALP, glucose, total protein, creatinine, albumin, globulin and A/G ratio) compare with control group.