“highly significant”

The relative radiosensitivity of the tumour in the OH compared to FFC nlice, virtually a measure of the effect of the changed genetic 5700 = 1-4 milieu, can be expressed as the ratio of the two LDzio S, 3950 4 (+ 0-05*). The magnitude of this ratio compared to its standard error shows the difference in radiosensitivity of the two groups to be highly significant (p < 0-0001).

Similarity of gene expression between the two groups was highly significant ( p = 1.0 e-323).

The difference between pathogenic and benign SVs was highly significant (rare versus common OR = 13.06, P = 5.43 × 10 - 323 , Fisher’s Exact Test).

4 C) and, although the overlap is small, it is highly significant compared with randomly reshuffled genomic regions ( P <10 −320 ; Fig. 4 C).

2d ) is highly significant for all possible overlaps between the stages (hypergeometric test, p < 1.921718e- 319 ) allowing for using of these differentially methylated CGs as peripheral markers of HCC.

Using (Log 2 [ β /(1 – β )]=0) as cutoff, Fisher’s exact test shows highly significant interdependence between gene expression and DNA methylation in the promoter region ( P = 4.5E-315) ( Figure 3 A).

Both conditions shared a highly significant overlap in their DEGs (396 overlapping up-regulated and 445 down-regulated DEGs; P < 10 −314 for both comparisons) and similarly regulated several direct YAP1 downstream target genes ( Supplemental Fig.

A χ 2 test ( supplementary table S1 , Supplementary Material online) revealed a highly significant overrepresentation of new–new and old–old node connections within the MMM12+ network, whether using OMA groups ( P < 1.1E – 311) (as is shown in fig. 1 B ) or MAP clusters ( P < 1.1E – 311).

This marker is a highly significant eQTL for MYOM2 on eQTLGen (P = 3.2717 × 10 –310 ) and GTEx (P = 9.5 × 10 –20 ) in whole blood.

Considering all tested SNPs in open chromatin peaks (the majority of which presumably have no true effect on chromatin accessibility), the correlation is more modest, though highly significant (iPSC correlation 0.12; P < 10 −308 ).

All of the overlap between pairs of cohorts mentioned above was highly significant (Fisher’s exact p < 1×10 -308 ); however, a caveat of this analysis is that the four brain regions were sampled from the same set of individuals.

The overlap between DroFN and the Drosophila proteome interaction map (DPiM [ 44 ]) was highly significant (Fisher Exact Test p < 10 −308 ).

Finally, introns and lincRNAs have a more tolerant gwRVIS score distribution that more closely resembles the distribution from intergenic regions, but due to the sheer size of the corresponding score lists the divergence remains highly significant (median scores: −0.050, −0.0015; Mann–Whitney U vs. intergenic: p < 1 × 10 −308 and p = 2.6 × 10 −168 , respectively).

Analysis of breast cancer transcriptomes (METABRIC cohort) also evidenced a very good correlation between the expression of FOLR2 and those of genes of the “anti-inflammatory gene set”, which reached statistical significance in most cases ( Figure 2 C), and was highly significant for CD163 (Pearson: 0.72; p = 1.71 × 10 −308 ) and even CD68 (Pearson: 0.59; p = 1.25 × 10 −176 ), another widely used marker for macrophage identification ( Figure 2 C).

We note that the P -value of the Spearman correlation was highly significant in every single case ( P -value <2e-308) because of the large number of data-points.

These included four differentially methylated CpGs associated with eGFR; a highly significant cg21961721 within SLC27A3 ( p < 2.2 × 10 −308 ), two intergenic CpGs between ZNF788P and ZNF625-ZNF20 (cg17944885; p = 3.7 × 10 −13 and cg25544931; p = 2.1 × 10 −5 ), and cg05165263 within the IRF2 gene ( p = 6.6 × 10 −5 ).

In consistent with this, the association between rs4759076 and mean platelet volume is highly significant ( p = 2.2 × 10 −308 ) [ 30 ].

22A ) and revealed a highly significant correlation of effect sizes (Spearman’s rank correlation) between both types of variants ( r = 0.85, P < 2.2E−308).

Although the number of shared hyperDMRs ( n = 2760) drastically outnumbered the shared hypoDMRs ( n = 195), both were highly significant ( p < 2.2E − 308 and p < 6.0E − 199, respectively, hypergeometric tests, using as background 500 bp genomic regions with at least one CpG and MeDIP and/or MRE signal in at least one sample) (Methods and Fig. 1a ).

In each case, the overlap was highly significant ( p <2.23×10 −308 for all comparisons, hypergeometric test).

The difference between the abundance of MIKC-only and non-MIKC-only prospective tetramers is highly significant, according to a Mann-Whitney U test ( U = 117.5; p < 2.6 × 10 -308 ).

In independent prespecified validation, the MA-PRS was a highly significant predictor of BC, after accounting for family cancer history, in the overall cohort (OR per standard deviation, 1.43; 95% CI, 1.40 to 1.46; P = 8.6 × 10 –308 ) and within each self-reported ancestry (Table 2 ).

Treatment of WT U-2 OS cells with arsenite showed a highly significant and global shortening of RNA upon stress (Mann–Whitney, p-value<10 –307 ) in stark contrast to ΔΔG3BP1/2 cells that showed substantially less shortening (Mann–Whitney, p-value<10 –5 ) ( Figure 6e , Figure 6—figure supplement 1g and h ).

The analysis of the pathogenic variant in the three main breeds with 96 cases resulted in a highly significant association (p = 6.62x10 -303 ) with CMO.

Prior to pleiotropy test, analysis of genetic correlation between the traits showed a highly significant genetic correlation between t-tau and p-tau181 ( p = 6.99 × 10 −303 ), however, correlation of these two traits with Aβ42 was not significant (p Aβ42 vs t-tau = 0.25 and p Aβ42 vs p-tau181 = 0.27).