“highly significant”

PTPs showed a highly significant pattern of positive selection ( p < 0.0001) using the M-K test, despite having an average dN/dS below 1.

All heritability estimates were highly significant ( p < 0.0001).

By definition, there was a highly significant difference in preoperative third ventricular diameter and FOHR between group I and II ( p < 0.0001).

Thus, considering the JAK-STAT pathway, there was a highly significant difference in mutation patterns in EATLs and MEITLs (p < 0.0001).

As demonstrated in this figure, there was a highly significant difference between the mean values of the two tested groups ( p < 0.0001).

Predictors of flare in the whole population Whole population multivariable Cox regression model, including selected variables from each analytical dimension ( table 2 ) and corrected for sex and age at the time of MTX withdrawal, confirmed the highly significant effect of the serological status (ACPA positivity) (HR: 4.20; 95% CI 2.37 to 7.44; p<0.0001) on the prediction of time-to-flare as previously observed in independent and more heterogeneous cohorts.

Much of this gap and the highly significant difference in the overall distribution of clinical outcomes (chi-square = 108.87, df = 5, p < 0.0001) is likely to reflect triage-related case selection rather than a true difference in diagnostic accuracy.

Furthermore, the clinical score differences on day four revealed highly significant intergroup variations, with P-values of <0.0001 for LPS + DH-HQ vs LPS, 0.0005 for LPS + DH-HQ vs LPS + DH, and 0.0028 for LPS + DH-HQ vs LPS + HQ (P < 0.005) ( Figure 14A ).

Backward logistic regression model defining significant predictors for mortality was highly significant (Nagelkerke R 2 : 0.51, P < .0001) (Table 3 ).

The point-by-point comparison of Carto-derived and OpenEP-derived interpolated local activation time maps revealed a highly significant correlation between these two metrics ( R 2 = 0.8892, P < 0.0001) ( Figure 6B ).

A global test for differences was highly significant (p<0·0001), as was a test for trend (p<0·0001, figure 3 ).

A highly significant difference in the surface roughness for the TiT group in compare to the TiM and Zr groups for all parameters ( p < 0.0001). 3.2.

Multiple Conditions Matrix Results The relationship between obesity and the multiple conditions matrix (Table 1 ) was highly significant ( P < 0.0001) and is shown in Table 4 .

By aggregating the two subgroups with low risk and three subgroups with medium risk, patients could be assigned to three risk groups (high, medium, low) with a highly significant ( p < 0.0001) five-fold difference in risk (Table 5 and insert in Fig. 2 ).

ELISA results showed that the Giardia induced a highly significant increase in the secretion of IL-6, IL-12 p40 and TNF-α compared to the control group (IL-6: ANOVA, F (4, 10) = 1.116, p < 0.0001; IL-12 p40: ANOVA, F (4, 10) = 0.6885, p < 0.0001; TNF-α: ANOVA, F (4, 10) = 1.990, p < 0.0001) (Fig. 2 a–c).

The models highlighted below were all highly significant ( p < 0.0001).

In animals subjected to the streptozotocin protocol (STZ-DPN), there was a highly significant ( p < 0.0001) reduction (95%) in PWT (>0.12 g i.e., static mechanical allodynia) which was restored to a level that was comparable to the saline-treated group (>2.5 g) by the dose of gabapentin (75 mg/kg) as the positive control standard drug ( Figures 1A–C ).

All pairwise comparisons show that differences between these size distributions are highly significant (P<0.0001, 2-tailed T-tests with unequal variances).

In all implant sites, we found highly significant correlations between peak insertion torque and mean ISQ ( r = .78, p < . 0001 ), preoperative BV/TV and peak insertion torque ( r = .90, p < . 0001 ), as well as between preoperative BV/TV and mean ISQ ( r = .64, p < . 001 ) (Table 1 , Figure 2 ).

Due to the high number of terms compared for each category (see Materials and Methods), this difference is highly significant (P<0.0001).

Eosinophil count reduction was higher in group B (96.1%) as compared with group C (85.4%) and group A (66.3%), with highly significant ( P = 0.0001) differences.

Regional comparison (Paired t-test) In contrast, a highly significant difference was observed between the maxillary and mandibular vertical components within the same specimens ( p < 0.0001).

The highly significant p values ( p < 0.0001) showed that there was a significant change in mean value from baseline for all three variables.

In our dataset, the centroid size may predict 8.5% of the total shape changes and there is a highly significant covariation between the bony labyrinth shape and the centroid size (p-value < 0.0001).

Exercise tolerance There was a highly significant variance in the exercise duration (expressed as percent compared to baseline) in the five groups (F = 93.3, P < 0.0001, Fig. 5 ).