“highly significant”

For each of the RD scores and for the DLQI, repeated measures analyses considering group, treatment week (as an ordinal variable, 0–7) and the group–week interaction identified a consistent, highly significant ( p < 0·0001) association between outcome score and treatment week, with significantly and increasingly higher scores over time.

Creatinine could not be used, given the highly significant association between urinary creatinine and BMI ( ρ =0·15; P <0·0001).

As expected, the main effect of Load was highly significant, reflecting progressive APS decreases with increasing loads ( F (2,76) = 21.46, P = 0.0001).

Figure 6 (left panel) demonstrates that, within these 702 node-positive patients, a highly significant correlation ( P < 0.0001) existed between the numbers of RNM at presentation and the rates of LRR through 15 postoperative years.

The one-way ANOVA conducted for testing significance of the mean iH O among the six populations investigated was highly significant: F 5,172 = 31.92, p < 0.0001).

Equally, there is a highly significant decreasing trend of both types of tumour with UVR-cumulative radiant exposure ( p < 0.0001).

When analyzed as a mean of all GLU injections at the same dose, the oxygen increase was highly significant ( F (12,240) = 4.13 and F (12,900) = 5.33 for slow- and rapid time resolutions; p < 0.0001), it appeared with ~40-s latency after injection onset, and peaked 30–40 s after injection offset.

Test Treatment C demonstrated highly significant increases of 17.48 ± 1.79 or 34.85% (p < 0.0001) at day 30 when compared to the baseline and 22.42 ± 9.1 or 73.67% (p < 0.0001) at day 90.

Significance levels were denoted as follows: * p < 0.05 (significant); ** p < 0.01 (very significant); *** p < 0.001 (highly significant); **** p < 0.0001 (extremely significant); and ns, p > 0.05 (not significant). 3.

SCFA levels increased by approximately one order of magnitude compared to the substrate-free control, and all differences were highly significant (**** p ≤ 0.0001).

The mixed-effects model analysis indicates highly significant effects of time, treatment groups, and their interaction on hepatocyte viability ( p < 0.0001 for all).

The differences were highly significant ( P < 0.0001).

On the contrary, in WB-irradiated mice, the average percentage of apoptosis was 14.5% ± 0.76, a highly significant value compared to the unirradiated group ( p < 0.0001; Figure 7 a–e).

The same comparative analysis showed a highly significant differential in detection of VOUS from 14.2% to 20.2% (Chi-squared p value <0.0001).

Our sample size justification is supported by prior work [ 25 ], which identified 57 differentially expressed ncRNAs in the hippocampus of stressed rats, with several showing highly significant differences ( p < 0.0001) using only 7–8 animals per group.

Also, there was a highly significant association ( p -value <0.0001) between each trough concentration, peak concentration, AUCτ, AUC 24h , Cl, V d with AKI occurrence, which indicates that these pharmacokinetic parameters would be considered as suitable parameters in vancomycin-induced AKI prediction.

CD19 + CCR7 + showed a highly significant decrease on day 7 ( P < 0.0001), followed by a further significant reduction on day 14 compared to day 3 and baseline.

Accordingly, here we detected a significant reduction in Hsp90 transcript levels of both isoforms in TGFβ-activated fibroblasts treated with mKate2 10K-EVs-CTPRAu, and a highly significant reduction (****p < 0.0001) by mKate2 100K-EVs-CTPRAu, 36 h after administration of EVs on TGFβ-activated fibroblasts (Figure 4 C-E).

In a second, larger randomized controlled trial at two sites, 39 participants received either active LVFS-guided UtPBM or sham; the active group showed a highly significant treatment × time benefit ( p < 0.0001) with an effect size of 1.5 at last follow-up on the opioid craving scale ( Schiffer et al., 2021 ).

Results: Highly significant correlation was observed between height and intercanine width, interpremolar width ( P < 0.0001), whereas correlation between height and the combined width of six anterior teeth and arch length was found to be not significant.

The z-test for the pooled estimate was highly significant (Z=5.13, P<0.0001).

This decrease was highly significant [Bl6: F (4.2, 78.9) = 6.82, p < 0.0001; C3H: F (3.9, 137) = 13.0, p < 0.0001].

As expected, the effect of condition (estimated in independent data) was highly significant ( sentences > nonwords , β = 1.897, t = 23.570, p < 0.0001) ( Fig. 2B, C ); in contrast, the main effect of localizer version was not significant ( speeded > standard , β = -0.068, t = -0.851, p = 0.395).

A linear mixed-effects model on neutrophil counts (log-transformed fold-change from BL) revealed a highly significant effect of treatment: NeuDep reduced post-stroke neutrophil presence by ~ 3.2-fold relative to controls ( p < 0.0001).

In both cases, the difference in the distribution of the individual cells among the classes of GFP intensities from the untreated and the Doxy-treated mice is highly significant ( p < 0.0001 by Chi square) ( Figures 3D , E ).