“highly significant”

A highly significant dose-dependent inhibition of colony formation (P<0.0001) was also found for MDA-MB-231 breast cancer cells with a similar maximum decrease of 24% (95% c.i.: 10–38) ( Figure 2b ).

The time to first parasitemia is shown in a plot of the Kaplan Meier survival estimate in Fig 2 , indicating no significant difference between ARR and RRR groups by blood smear ( P = .46) and by PCR ( P = .41) in contrast to highly significant differences between ARR and RRR compared to infectivity controls ( P < .0001).

Median age of children presenting for all SA assessments was 10 years (IQR 4–14 years), for PAN was 3.5 years (highly significant, Mann-Whitney U test Z score=6.84, p<0.0001).

GFC showed highly significant (P < 0.0001) improvements in before treatment versus after treatment in the WOMAC, KOOS, IKDC, and VAS scales used for the assessment of knee osteoarthritis.

Beta diversity based on Bray-Curtis dissimilarity showed significantly different community compositions by parity ( p < 0.05) in the first year of infant life, with parity-based community variation being highly significant at 2 months of life ( p = 0.0001) and this significance disappearing by 24 months of life ( Figure 1 ).

Linear regression modeling Linear modeling confirmed the highly significant relationship between PTH and vitamin D status (according to 25(OH)D; P < 0.0001; Table 2 ).

Our analysis revealed a total of 447 significant SNPs across the pearl millet genome associated with primary root growth from which, 109 SNPs were found highly significant with at least two other methods for association analysis at p-value <10 −4 ( Supplementary file 1 , Table S2).

Contrary to the negative correlation, a highly significant positive correlation (p<0.0001) found in these analyses.

When WT ovules were used, 59% of the assays showed pollen tubes growing toward WT ovules ( n =80), while only 10% of the pollen tubes grew toward the Scfrk1 -S1 ovules ( n =60), giving a highly significant P <0.0001 value in a two-sample binomial test.

Comparison between semiquantitative immunohistochemical evaluation and RT–PCR quantification of L1CAM transcripts resulted in a highly significant correlation (p < 0.0001; r s =0.663).

Furthermore, comparing datasets showed highly significant differences (Wilks’ lambda = 0.0119, F(40, 10687) = 592.4963, p < 0.0001), indicating distinct multivariate distributions among the datasets.

Two-way ANOVA showed a highly significant effect of time ( p < 0.0001), a significant effect of group ( p < 0.0001), and a significant interaction effect between the two groups ( p < 0.0001).

A main effect of Emotional Expression was highly significant ( F (5,245) = 78.15, p < 0.0001; effect size, η 2 = 0.615).

All the main and interaction effects were observed to be highly significant ( p < 0.0001).

Comparison of change in mean size of the lesion within group A and group B at 4 weeks Within-group analysis for Group A showed a highly significant reduction in lesion size from baseline (Figure 4 ) to the four-week endpoint (Figure 5 ), with a mean score change of 2.0+/- 0.95 (t = 8.16, df = 11, p < 0.0001).

Furthermore, matrine at 128 ng/mL had a very highly significant anti-BVDV effect compared to this extract at 4, 8, 16 and 32 ng/mL (P-value < 0.0001), and had a significant anti-BVDV effect compared to 64 ng/mL (P-value < 0.05).

The model is highly significant (F-statistic p -value < 0.0001), and the RMSE values suggest reasonable predictive accuracy.

Interestingly, cytology parameters also showed highly significant differences between benign lesions and healthy controls (all p < 0.0001).

At month 12, this finding was even highly significant for HLA class II ( p < 0.0001).

Its mode of action was clear and highly significant ( p < 0.0001; Supplementary Table S3 ).

The difference was also highly significant when the threshold was placed at 5% wound BSA (median 5.05 vs. 37.3 pg/mL, p < 0.0001) (Figure 2b ).

Submitting the magnitude of the PSA gain to a repeated measure ANOVA with the factors direction (horizontal/vertical), eye (right/left), and estimation approach (I/II/III) showed a highly significant main effect of the factor direction ( F (1,13) = 36.1; p < 1e-4) and no other significant ( p > 0.25) main or interaction effect.

This is highly significant in both the linear and quadratic term ( p < .0001).

For the Mania Scale, two-way repeated measures ANOVA with covariance for baseline showed a highly significant effect of time (F = 16.0, df = 2, 28, p < 0.0001) and a significant interaction of time and side of TMS (F = 5.2, df = 1.4, 19.2, p = 0.04, Greenhouse-Geisser-corrected).

There were no significant differences within the states with the exception of HDL cholesterol where differences were highly significant at p = 0.0001, Table 2 .