“highly significant”

Compared with population data, enrichment of SIX1 loss-of-function variants was highly significant (p=0.00003).

Compared to the untreated control, both treatment protocols resulted in a highly significant reduction in viable cell counts (t-test, t (5) = 14.30, p = 0.00003, ***), corresponding to a ~ 4 log10 reduction (Figs. 6 and 7 ).

In particular, CM-CF showed highly significant differences compared with U-CF ( P value = 0.00003), indicating a positive effect of the combination of mercerization and coating on CF stiffness.

Within the case group, a Jonckheere–Terpstra test for trend (based on 100,000 permutations) revealed a highly significant increasing trend across the three age strata (puppy, juvenile, adult; JT = 166.5, p = 3 × 10 −5 ) with the median VBI increased from 0.48 (puppy) to 0.55 (juvenile) and 0.57 (adult).

Highly significant differences were seen in plasmacytoid DCs (pDCs) (mock primed: 56.4±1.6; ArmΔGPC primed: 30.2±1.7, p = 0.00003), macrophages/monocytes (mock primed: 11.4±1.6; ArmΔGPC primed: 2.1±0.6, p = 0.0017) and FRCs (mock primed: 9.0±0.4; ArmΔGPC primed: 1.7±0.3, p = 0.000007) from primed and mock primed Cl13 infected mice ( Fig. 6A ).

filters F3+F4; 365 SNPs in 396) (Table 3 ), a highly significant difference was found in the final number of SNPs recovered with call rates ≥ 95%, (Chi-square Pearson = 17.40; p = 0.00003).

However, the KNN classifier trained on the exonic subset of features showed no statistically significant difference in BCR-free survival using a log-rank test ( p < 0.08) whereas the difference was highly significant for the non-exonic KNN classifier ( p < 0.00003).

Consistent with this, regression of second component dopamine responses to cues (0.2–0.6 s after the cue onset) onto value estimates of the superior model was highly significant ( Figure 4B , right, R 2 = 0.93, p=0.00003).

This highly significant enrichment of S-aromatic motifs within the low-reactivity group (p-value = 3 × 10 −5 ), allows us to conclude that the involved methionines exhibit a much lower reactivity than their non-interacting counterparts.

Furthermore, we also confirmed there was a highly significant correlation between MM and GS in this module (Cor = 0.47, p =3 e − 05) ( Figure 3(d) ).

In all cases, there was a clear bias of propagation in one orientation, which was highly significant ( P < 3 * 10 −5 ; 12 retinas aged P4–6; data not illustrated).

In these pairs, a slightly smaller but still highly significant difference was found, again with the luteus coding sequences associated with higher redness ( t = 4.4855, df = 65, p = 3.03 × 10 −5 ).

Serum FSH was elevated about two-fold (from 88 to 208 ng/ml) with a highly significant p-value (p = 3.07 x 10 −5 ), and LH was elevated about eight-fold (from 0.35 to 2.6 ng/ml), also with a significant p-value (p = 0.014; Fig 10C and 10D ).

In ER-positive patients, highly significant differences between patients with high vs. low CYP19A1 expression were observed with respect to OS ( P = 3.1 × 10 −5 ; Fig. 4 d), DFS ( P = 2.1 × 10 −4 ; Fig. 4 e), and MFS ( P = 1.5 × 10 −6 ; Fig. 4 f).

4a , the difference between groups was highly significant (Kruskal-Wallis, P = 3.107e-05).

This represents highly significant enrichment compared to such variants from gnomAD v2.1 (23 of 958 variants; one-sided Fisher’s Exact Test p -value = 3.15 × 10 –5 , odds ratio = 39.8).

By the 45th day, the group administered with a low dose exhibited significantly elevated L-carnitine levels relative to the control group ( p = 0.0129), whereas the high-dose group not only exceeded the low-dose group ( p = 0.013) but also demonstrated highly significant differences to the control group ( p = 3.15 × 10 −5 ). 3.2.

In the itpr mutant condition 50 down-regulated genes cluster in the mitochondrion ( Fig 2 ; CC) and a highly significant number (P = 3.2E−5) have the molecular function (MF) of oxido-reduction.

The assigned thresholds were then validated by examining the association between immunostaining scores of the HER-2 gene (HercepTest, DAKO, DK-2600, Glostrup, Denmark) and copy number states, that is, gains, no change and deletions, which was found to be highly significant (Pearson's correlation, r = 0.53, P = 3.2 × 10 -5 ).

The difference of S nontrem between pretreatment (−0.097) and at 4 years and beyond (1.197) was highly significant ( p = 3.22e‐05), whereas that of S trem was not (0.017 vs. 0.068; p = 0.73).

The difference is highly significant ( P = 3.3 × 10 −5 , Poisson distribution).

This highly significant overlap (odds ratio = 45.9, P < 3.3 × 10 −5 , permutation test, 30,000 times) provides an independent confirmation of our results.

Nevertheless, the association of rs1363713 with AF trait was highly significant ( P =3.34 × 10 −5 ), but not as significant as the CNV.

When the number of trophic niches occupied by members of clades was used in this model in place of the number of habitat types, we again found a highly significant result (multiple PGLS, p = 3.365 × 10 −5 , F = 14.62 on 2 & 29 d.f., adj.R 2 = 0.4523, N = 34).

rubidus collected from dung quadrats than those lacking dung, a highly significant difference ( p = 0.0000339, W = 4.15, df = 1, p < 0.01).